oaskiydtrojlcoyiinNinredlelimalesrSruNerapmNeostroNkoodNaibtYluyoaaasyldcunluraRruileiegssrNsunNiNgeanrcauhttsclMilsueditinenaaftyhiiogpoultodadrroeaatlUyrigPotudmclnkagfanyMiie]RitMprpdmborecrpealRomnoapinacvhntifpaohiltMdacacomdaeoPptoUaffMssuePinersdnotQinorsoalcasehrteafNdisnomleflUtldPniVnisoneopfwtturduailiKsonrrlnaotRmMmUnanohuiedisgirNmrrnsnaaenneoerre[tlntbangaetNsrocpeivyoesoeppbncdulroNaipnlyLrnNctmmaMnbgSeapnSeMPeljibfealtyPo[rnoRnpuauorleopitdsnutrere[saaPaltoaoayeatoiatnnimamamymimqMeRoaiMonftnieruvhUpirmnnmourraobibRdrneiytoliramdayirpuercrtRlsruraoicioneProyPtrSlesirmrucgnnuPlUniteitytrtcreleaacornpRuookniIaaplorhasRcVNeeesnUatoarcltMiooSsrtpssowiMscseennnaiicowalatnbpsgrdpmNarymmsslidanUtta]lNthwRercspNnoSbNbnNnstalaSmRnaeaenninntoahlmieeornubu[c]faebtbtRdbaanpohnnolndranaiteaeepdoPieottrknaUhmceNNmnPtigNnslookteonihniiegNotuliaatuttoeostaertocbngso]npciuiimrntueontrpanvncuMasbadrbaaaivyinsieneSrWueogUboiyrlSsWv]iPrsdmPiPvllaiianlnumgnvgomdnvosdiaaeieMigstpydSsphrSomehssdcnabeeMroSurSletntrNosaoncniMadguvtildioaedtelaynoynncptroadpslauoiledmuwlstlrnueaodtmdzidnramolfcunenigedeaanatyllcabdarrUeolbeessNuuinonbrlielMoRrtaidgocneieNsUnRcneamiNgeooeumptaioereyueerseoltrlaPuitruapltndaSiPnosnizhuouenlanrPsasonntcburnlaoiypralPralinrasNsamptmuifymnbdtMutyavPbsaerpuRpMeMNrbyPlcnuuPaePnMelpimtalafroooeNSpulgooeLnPayshdscceacilsiyelbnidapgniertiagetihhibnturloNooeyepeooNldmRaieteertPehatpnRterteevtreockiPneSesdanrkanlsul[lniostaryPbcPbnaeiRapiuadpePRPundRemgmiergnastoaPOhNaMdiTstoPcriPsgSirsafoN[r]oorumnTlloeynrrasnlluealafbsNcbroeotlndiuclRemuNlanmipalipcaybbtbdoeRurQeelli[e]ePNwadcmallzekndtovxRdaliugrrlmtaRrasiucyNnimrNlrilRtyyRarPRVaRhypsweeeodpRNWeissPSteems FJJ.25,.62003 157 :?,.,1993,50:93. I 1998,16:431.11G,G,BK.- 4,,,.:. DJJCF :-CA,1996,23:127. .,1998,16:432.12A,B,.- 5,.::-,- CECGA- .A,1998,,,.BJ,1999,83:591. 11:8.13,,,. JDCDCE- 6J,BJG,D.:: .,1998,17:467..,1999,18:559. 7A,AH.,-14.E.A 40-64.,1996,24:73.F,1997,55:2146. 8,.15,,,. AA-JCAA- .ICA,.:-,- 1998,1:201~202..,1998,81:215. BJ 9BJG,D,J.E16HJ,,EB.. :CAA-- .,1998,17:398..J,1997,158:830. 10KJ,C,E,. 4 福建省肿瘤医院病理科(350014)陈刚综述郑天荣审校 【】735.2【】A【】1002-2600(2003)06-0157-03 ,3,, 7 ,,11, Hαβ 。,。 4(C-4,2IK4 4),4/4, IKIKAFIK IK4AFIK4AF 1619,161953 4/6(C-4/6)。 IK4 ,53 16,4() 1、2IK4AF ,41619、 IK,CDK4/6, 。()4/6,4/6 DDCDKCDK 1IK4,,E2F, 3 4(1、2)1993→。 IKCDKG1G1 8IK4 4, CDK16 IK4 。1994,K-,16-4/6/- CDKCDKD 4、5 921,3 。 AF (126、307、11)2。1995 19, CDK 6 ,IK4(A ,D2 F,AF),1,IK4A53,53。 AF 。4 αAβAαACDK192, DC IK4 616,148, CDKD2,53 AF 16,。19, DG1βA,53,53, IK4 53→→, 169,19D,16G1G2 AF 。192-53-21 ,GG。IK41G1G2D 12 9、10 11,11 αβαAβAαβ,。D2 IK4AF 23,16192,532 D |
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