575,2122,001218,90,392,12,0,624,,)20,298,60,0()2,,)8244,,,622,(9185,(,0195980102(,200,1554,,93)5(27(0),9707571(0(11,,,2(,21,8,8726)2(09)14730(8,8(9,977(1,,7)0027912,2,1)10,7(51,,,,72)4(0,)5(2,1,724(4),0228(),4(453125,,,21,058211,37,22,)1(5)02)2,46194,872,8,89002365,20,92665,,71,5)06012249)4)1,6,91,,2393)221,0220,81374917,0,13,929)(5580,,68082811,02,,,8431,012 associatedwithmismatchrepairdeficiencyinhumanadvancedcolor- FHIT ectalcarcinoma[J].BrJCancer:l-. 、。FHIT [].KAI 。 [J].:-. 、 []RozLGramegnaMIshiiHetal.Restorationoffragilehistidine FHITtriadFHITexpressioninducesapoptosisandsuppressestumorige- [] nicityinlungandcervicalcancercelllines[J].ProcNatlAcadSci 。 USA:. MSH、 []TzaoCTsaiHYChenJTetal.''CpGislandhypermethylation MSH andaberranttranscriptsplicingbothcontributetotheinactivationof [] 、。SenguptaMSH theFHITgeneinresectednon-smallcelllungcancer[J].EurJ [] 。MoriFHITCancer:. []RohrUPRehfeldNGeddertHetal.Prognosticrelevanceof MSH fragilehistidinetriadproteinexpressioninpatientswithsmallcell MSHFHIT lungcancer[J].ClinCancerRes:-. FHIT。 []deFraipontFMoro-SibilotDMichellandSetal.Promotermeth- [] SardTunelFHTT ylationofgenesinbronchiallavages:amarkerforearlydiagnosisof HBAK primaryandrelapsingnon-smallcelllungcancer[J].LungCancer :-. pp。FHIT []SenguptaSChakrabartiSRoyA.InactivationofhumanmutL MSH。 homologandmutShomologgenesinheadandnecksquamous p cellcarcinomatumorsandleukoplakiasamplesbypromoterhyperm- 、 ethylationanditsrelationwithmicrosatelliteinstabilityphenotype 。p [J].Cancer:-. []MoriMMimoriKMasudaTetal.AbsenceofMshproteinex- pressionisassociatedwithalterationintheFHITlocusandFHIT ;p proteinexpressionincolorectalcarcinoma[J].CancerRes 。 :-. FHIT、MSHp []SardLAccomeroPTornielliSetal.Thetumor-suppressorgene 、 FHITisinvolvedintheregulationofapoptosisandincellcyclecon- 。trol[J].ProcNatlAcadSciUSA:-. :-- : []AndachiHYashimaKKedaMetal.ReducedFhitexpressionis ·· 临清市老赵庄镇卫生院山东临清 .%。 ~
:、 。。 。 :; 。 ~;~a。: minDNA .mg S。 cm、 ~d。: 、。。 .%.%:-- |
|