同期内使用3种PDE5抑制剂治疗ED的经验

))=
!" # " $%&’!"# (%’"
(,-.%/,& 0%12/,& %3 4/52%&%67
)+ " 8,2’ )+
" 9:;< ;:
! )
#
!’ )’ =!>!
# " 9:;< ;:
# !! " 9:;< ;: ""!
!"> ?? !@
# ! +)
+@’!)A <) +?’+?A =" ?!’?!A "9:;<
# 9:;<
" 9:;< ;:
$
# ! " 9:;< ;:
"" 9:;<
9:;<
#
B<
D
"
C=@? ’!# # 4# # !@B"<@! )+ "B))=B"
!"#$%&$’($ ) +,&’- ./%$$ 0/),#/)1&$,2$%3,$ .4#$ < 5’/&6&2)%, &’ 2/$ 738$ 0$%&)1
)% 2/$ .%$328$’2 ) !%$(2&9$ :4,;’(2&)’
! )
EF4(G H.BI.,% G4J 9./6
!! "#$%&’(#)’ + ,&-./ )! 0-1)12 + 3)4&-./ 56%71 58$1’%- 912:6%) ,)1;#&81’/ 0:#).46 912:6%) =!>!
0:1)%
0&$)4#)2# ’ <53=> 91?71%
<6,2%3(2 # !"#$%&’($ K% %LMN2ON ,/5 P%QR,2N -SN N33NP-M ,/5 ,5ON2MN NON/-M %3 -SN -S2NN RS%MRS%5.NM-N2,MN -7RN < 9:;B< ./S.L.B
-%2M M.5N/,3.& O,5./,3.& ,/5 -,5,/,3.& 1MN5 ./ -SN M,QN RN2.%5 3%2 -SN -2N,-QN/- %3 N2NP-.&N 57M31/P-.%/ ;: ’ # )$&+,- 4 -%-,& %3 "!!
;: R,-.N/-M TN2N -2N,-N5 T.-S -SN -S2NN 9:;B< ./S.L.-%2M ./ -SN M,QN RN2.%5 !"> T.-S M.5N/,3.& !@ T.-S O,5./,3.& ,/5 ?? T.-S -,5,/,B
3.& ,/5 3%&&%TN5 1R 3%2 )B!! Q%/-SM’ KSN.2 N33NP-M TN2N P%QR,2N5’ # .$-/0&- H.5N/,3.& R2%51PN5 M,-.M3,P-%27 N33NP- ./ +) R,-.N/-M
+@’!)A O,5./,3.& ./ =" ?!’?!A ,/5 -,5,/,3.& ./ <) +?’+?A 2NMRNP-.ON&7’ 4/5 -SN N33.P,P7 2,-NM %3 M.5N/,3.& O,5./,3.&
,/5 -,5,/,3.& ./ -SN -2N,-QN/- %3 ;: T.-S R2NQ,-12N NU,P1&,-.%/ TN2N <<’<=A >>’>>A ,/5 >)’"A 2NMRNP-.ON&7’ J12 M-157 ,&M%
MS%TN5 -S,- -SN 7%1/6 ,/5 -SN /NT&7 Q,22.N5 R2N3N22N5 O,5./,3.& -SN Q.55&NB,6N5 PS%MN -,5,/,3.& ,/5 -SN %&5N2 ,/5 &%/6B-N2Q 1MN2M
-N/5 -% -,VN M.5N/,3.&’ KSN Q,./ 2N,M%/M 3%2 5.MP%/-./1./6 -SN 1MN %3 -SN -S2NN ./S.L.-%2M TN2N -SN.2 S.6S R2.PN ./P%QR&N-N N33NP- ,/5 -SN
R,-.N/-MWT%227 ,L%1- -SN.2 ,5ON2MN ,P-.%/’ # 1+2%0/-’+2 KSN -S2NN 9:;B< ./S.L.-%2M P,/ R2%51PN L,M.P,&&7 M.Q.&,2 N33NP-M %/ ;: ,&&
T.-S M,3N-7 ,/5 3NT Q.&5 ,5ON2MN NON/-M’ 3 45&0 6 72,8+0 9::; <= = 99>?9=9
=$4 >)%1, N2NP-.&N 57M31/P-.%/ -2N,-QN/- RS%MRS%5.NM-N2,MN -7RN < ./S.L.-%2
" )=B!B! )=B!)B"
!@""B
’ ! ! ! ’ %#"& "# ))+
(! ’ %#"&
! ! "# $%#"&
/9:;< (5 /=< ’ %#"$& >?=>:>@ABC DC? E>FF’ (
"# G9@>’ ’’( "#
H8< IBC ! J>E; /9E9?9F>; K9E>?9F>;
) ,)4 3) (2 )’ 2&
’ ,’4 (&2 -2 24 2(
!!
2 ,24 -’ ’3 ( (&
& ,&4 (& ( ( 2
)& + ,)- - ’
- , (+ 3 & 2
%#"& "# ’’( ’
2 3(53(6 ’ (
.%/ 010
"#
& 4 ’
3
"# %#"&
(’2 33 (4 K1#
"#
( 78
& (
"# ( (
) 78 ’ (
+ ’ )
) ’
"!
2 ’ (
2 ) )
(( )
4( -+546 ’ ’
-- +&56 ++ +5-6 ’- =
’ %#"& "#
( 78
& ,) ) ,- ( ,)& 78 )
,() ) 78 2 ,’ ) 78 ,( 78 ,& 78 2 ’ , &
( ,( ) 78 ( ,) ) 78 , )&78
) ,( 78 )2 ,’- =
( 78 ,& 78
-)5)+6 (+5-6 (45-6
’ %#"& (
! ! ’ E
"#
010 3
%#"&
(& ,’ 7>?
’ %#"& "# "# (&
() (
+) ( 78 & 78
(
)4 )& 78 (2 +45()6 &)
) 78 )3 ( 78 )) & 78 ) +35+36 (4 ’ ’ ) ’ ( 2
-’ ) 78’’ ( 78)- & 78 & ’
; ,,: ! )+
!!
$# $#
"#$% $# %%1%%2
)% 345
&&$’ &&$’(% +, 345
$# $#
)
6
778&9
: ;
"!
$#
+ "#$% $# +
+ "#$%
$#
$#
+
"#$%
) $#
),
) ! /<=9>5 / ?4@A4<5> ’ ?>AB9CD45 & !" #$% .ED FDGGDHC4I5D99F9H% +
CED=@CH>3 >G JE<=3A>K4H CED== $# <5 45CD=5<(
C4>559D59@9 J<5DA =DJ>=C L 1 &5C L &3J>C 8D9 ,,0 )6
+ ,:()+1
-./
! 1 $#&.7 7MNN
L 1 ,,6 ) 6 %:,(%:1
$#
+ ! ! 1 L 1
!
,,6 ) 6 %60 %6O1
0 ! PA>CQ . RCQ 8 !" #$1 SET B> J" # $
C4AD BT9G@5HC4>5 5 DGGDHC4ID CED=%
L 1 &5C L &3J>C 8D9 ,,% ): ) (01
% ! ! 1
! " # $
L 1 ,,6 ) ;
0
:0 :001
6 ! ! 1 $#
L 1 ,,0 )) % ))6O()):,1
$#
: ! "=T>= L 7E<=A4J &1 "=D35 U4AA 3DB4H=D) "#$%
H45D 9>H4DCT 3DDC45K YCA<5C< ,,61%()1
; ! R>5CU L \=>BD=4H] ?Y !" #$1 YZY K@4BDA45D >5
CED JE<=3A>K4H 3<5G J=D35 L 1 L
Z=>A ,,0 ): ) O,(O01
!