Inhibitors?Screening Libraries?ProteinsMedChemExpressHPK1-IN-33Cat. No
.:HY-149206分子式:C??H??ClFN?分子量:370.81作用靶点:MAP4K作用通路:MAPK/ERK Pathw
ay储存方式:Please store the product under the recommended conditions
in the Certificate of Analysis.BIOLOGICAL ACTIVITY生物活性HPK1-IN-33
(compound 21) 是一种有效的造血祖细胞激酶 1 (HPK1) 抑制剂，Ki 值为 1.7 μM。HPK1-IN-33
抑制 IL-2 的产生，在 Jurkat WT 和 Jurkat HPK1 KO 细胞中的 EC50 分别为 286 和 >100
00 nM [1]。IC50 & TargetHPK11.7 nM (Ki)REFERENCESGallego RA, et al
. Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrr
olopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1. J
Med Chem. 2023 Mar 20.McePdfHeightCaution: Product has not been f
ully validated for medical applications.For research use only.1/1
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