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料峭春风吹酒醒，微冷，山头斜照却相迎。
回首向来萧瑟处，归去，也无风雨也无晴。 ----苏东坡 
间充质干细胞（mesenchymal stem cells）（相关科普见本公众号《神秘的间充质干细胞—干细胞中的007》），在技术江湖中称MSC。MSC来源广泛，在骨髓、脐带、脂肪、脐血、胎盘、牙髓等均发现有间充质干细胞的存在。然而，不同来源的MSC被不同的机构赋予了不同的“定义”、“神力”，大有在某些所谓“健康管理”的机构中形成论剑之势。 
于是乎，南山小仙和步步先生在看文献看得两眼空洞、六神无主之余，开始了一段看起来毫不严谨的对话： 
如果要在临床上研究及应用，除了从来源上考虑 MSC 的生物学差异性外，还必须要考虑到其提取的可行性、可提取的细胞数量、伦理学上的限制等等，所以，没有最好的，只有最合适的！ 那些年，曾经咀嚼过的一点文献：
NogamiM,Tsuno H, Koike C,et al． Isolation and characterization ofhuman amniotic mesenchymal stem cells and their chondrogenic dif-ferentiation［J, Transplantation,2012, 93(12):1221 －1228． Chen K, Wang D, Du WT, et al． Human umbilical cord mesenchymal stem cellshUC - MSCs exert immunosuppressiveactivities through aPGE2- dependent mechanism［J. Clin Immunol， 2010, 135(3):448－458． ZhuX,Shi W,Tai W, et al.The comparison of biological character-isticsand multilineage differentiation of bone marrow and adipose derived mesenchymalstem cells［J］. Cell Tissue Res. 2012, 350(2):277-287． ChoudheryMS, Badowski M, Muise A, et al. Comparison of human mesenchymalstem cells derived from adipose and cord tissue［J．Cytotherapy， 2013， 15(3):330 -343． YooKH, Jang IK, Lee MW, et al． Comparison of immunomodulatory propertiesof mesenchymal stem cells derived from adult human tis-sues［J］. Cell Immunol, 2009,259(2):150 -156． 刘蒙，杨少光，刘鹏霞，等．人骨髓和脐带来源间充质干细胞体外支持造血能力的比较研究［J］．中国实验血液学杂志， 2009，17(5):1294 －1300． JinX, Jin X, Jung JE, et al． Cell surface Nestin is abiomarker for gli-oma stem cells［J］． Biochem Biophys Res Commun,2013,433(4):496 -501． Alegre- Aguarón E, Desportes P, García -lvarez F,et al. Differ-ences in surface marker expression and chondrogenic potentiala-mong various tissue - derived mesenchymal cells from elderly pa-tients with osteoarthritis［J］. Cells Tissues Organs， 2012， 196(3):231 －240． TsaiCC,Hung SC. Functional roles of pluripotencytranscription factors in mesenchymal stem cells［J］. Cell Cycle, 2012, 11(20):3711 -3712． BakshD, Yao R, Tuan RS． Comparison of proliferative and multilin-eagedifferentiation potential of human mesenchymal stem cells de-rived fromumbilical cord and bone marrow［J］． Stem Cells,2007,25(6):1384 -1392 Roura S, Bagó JR, Soler - Botija C, et al. Human umbilical cord blood － derived mesenchymal stem cellspromote vascular growth invivo［J］. Plos One, 2012, 7(11):e49447 YuJ, Cao H, Yang J． In vivo hepatic differentiationof mesenchymal stem cells from human umbilical cord blood after transplantationin-to mice with liver injury［J. Biochem Biophys Res Commun,2012,422(4):539 －545． AnJH,Park H, Song JA. Transplantation of humanumbilical cord blood- derived mesenchymal stem cells or their conditioned medi-um preventsbone loss in ovariectomized nude mice［J］. Tissue Eng Part A， 2013,19(5 -6):685 -696．
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