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桑黄素是一种存在于许多膳食植物中的黄酮类化合物，可以减少大鼠滑膜血管的数量并改善胶原诱导的关节炎（CIA）。在此，中国药科大学中药学院中药药理系的Mengfan Yue、Ni Zeng、Yufeng Xia等人针对PPARγ途径研究了其潜在机制。  在体外，可以通过伤口愈合和transwell实验来观察桑黄素对HUVECs迁移的影响。桑黄素抑制VEGF诱导的HUVECs迁移和血管形成，PPARγ拮抗剂GW9662或siPPARγ逆转了这种作用。分子对接和竞争性结合分析表明，桑黄素可以与PPARγ结合。桑黄素以PPARγ依赖性方式增加PDK4和CD36的表达，并增加PPARγ质粒转染细胞的荧光素酶活性，表明桑黄素可以在结合后激活PPARγ。此外，桑黄素增加PTEN的表达，PTEN是抑制血管生成的PPARγ靶基因，并抑制PI3K/Akt信号传导。GW9662和siPPARγ降低了桑黄素对PTEN-PI3K/Akt通路的影响。体内研究表明，桑黄素改善大鼠CIA、降低滑膜血管生成并上调滑膜中PTEN的表达，GW9662几乎完全消除了滑膜。 桑黄素是PPARγ的潜在兴奋剂，其通过PPARγ-PTEN-PI3K/Akt途径减弱滑膜血管生成和关节炎。 该文章《Morin Exerts Anti‐Arthritic Effects by Attenuating Synovial Angiogenesis Via Activation of Peroxisome Proliferator Activated Receptor γ》2018年8月30日发表于《Molecular Nutrition and Food Research》，DOI: 10.1002/mnfr.201800202。点击下方阅读原文即可查看摘要原文。 翻译/编辑：袁艺；责任编辑：张睿梅 图片来源于百度图片 Food Science and Human Wellness is an international peer-reviewed journal that provides a forum for the dissemination of the latest scientific results in food science, nutriology, immunology and cross-field research. Articles must present information that is novel, has high impact and interest, and is of high scientific quality. By their effort, it has been developed to promote the public awareness on diet, advocate healthy diet, reduce the harm caused by unreasonable dietary habit, and directs healthy food development for food industrial producers. Scope includes the following topics of research papers, prospective summarizes and comments: · Food Biochemistry: comprehensive studies involving incarbohydrates, proteins and enzymes, lipids, nucleic acids, vitamins, minerals, phytochemicals, genomics, genetic/cell/enzymatic engineering, proteomics andmetabonomics, etc. · Food Microbiology: includes physiology, genetics andbehavior of microorganisms, microbial interaction, microbial toxin, foodpathogens, biocontrol, predictive microbiology and microbial risk assessment, etc. · Nutrition and Immunology: food nutrition in the molecular leveland in clinical studies, bioactive compounds/ingredients and their functionalevaluations, cytokines, food allergies, molecular immunology, immunobiology and immunogenetics, etc. · Food Safety and Toxicology: studies on foodborne diseases, hazard analysis and toxicological evaluations, etc 文章免费阅读： http://www./journal/food-science-and-human-wellness/vol/1/issue/1 投稿： https://www.journals./food-science-and-human-wellness |
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