几十年前,医药研发人员查询相关数据,囊萤映雪,一本本书一篇篇文献地浏览。如今身处互联网时代,拿出手机一键查询,知晓天下事,医药研发数据也悉数获知。 医药领域信息广阔,从药物设计到合成再到活性试验,从临床前到临床试验再到批准上市,从药品到医疗器械,从患者到医生等等,相关的医药数据库可多达成百上千个。对于医药研发人员而言,有价值的医药数据库大大提升他们的工作效率,也在一定程度上避免资源浪费。然而不少医药数据库为商业数据库,每年收费几十万到上百万不等,大部分医药研发人员望而却步。不过,市场上仍有大部分学术型医药数据库是免费的,小编今天就为大家献上常用的医药数据库,附上各常用医药数据库的引用次数及z-index。 疾病类1. NCBI - National Center for BiotechnologyInformation Types:disease、DNA、drug and chemical compound、基因表达、literature、metadata、phenotype、protein、RNA、standard,ontology and nomenclature Location:United States 网址:http://www.ncbi.nlm./ Citation:16174 z-index:359.42 2. COSMIC-Catalogue Of Somatic Mutations In Cancer Types:disease、DNA Location:United Kingdom 网址:http://cancer. Citation:4018 z-index:261.1 Types:disease、DNA、基因表达、phenotype Location:United States 网址:http://www.informatics./ Citation:2658 z-index:126.57 4. HGMD-The Human Gene Mutation Database Types:disease、DNA Location:United Kingdom 网址:http://www. Citation:2655 z-index:123.90 5. HPO-Human Phenotype Ontology Types:disease、phenotype Location:United States 网址:http://www./ Citation:975 z-index:97.50 6. CTD-Comparative Ttoxicogenomics Database Types:disease、interaction and network Location:United States 网址:http:/// Citation:1016 z-index:67.73 7. Atlasof Genetics and Cytogenetics in Oncology and Haematolog Types:disease、DNA 网址:http:/// Location:France Citation:1188 z-index:66.00 Types:disease、RNA Location:China 网址:http://www./ Citation:537 z-index:59.67 9. PlasmoDB-Plasmodium Genomics Resourse Types:disease、DNA、metabolic and signaling pathway Location:United States 网址:http:///plasmo/ Citation:413 z-index:45.89 Types:disease、standard ontology and nomenclature Location:United States 网址:http://www./ Citation:248 z-index:40.92 DNA类Types:DNA、protein、RNA Location:United Kingdom 网址:http://www./ Citation:12662 z-index:775.55 Types:DNA Location:United States 网址:http://www.ncbi.nlm./genbank/ Citation:46415 z-index:576.67 3. GWASCatalog Types:DNA、phenotype Location:United Kingdom 网址:http://www./gwas/ Citation:3886 z-index:431.78 4. UCSCGenome Browser- University of California,Santa Cruz Genome Browser Types:DNA、基因表达、protein、RNA Location:United States 网址:http://genome./ Citation:6429 z-index:428.60 5. NCBI-National Center for Biotechnology Information Types:disease、DNA、drug and chemical compound、基因表达、literature、metadata、phenotype、protein、RNA、standard,ontology and nomenclature Location:United States 网址:http://www.ncbi.nlm./ Citation:16174 z-index:356.42 6. COSMIC-Catalogue of Somatic Mutations in Cancer Types:disease、DNA Location:United Kingdom 网址:http://cancer./ Citation:4018 z-index:261.17 7. TRANSFAC-a database on transcription factors and their DNA binding sites Types:DNA、基因表达、interaction and network、protein、RNA Location:Germany 网址:http://www./pub/databases.html Citation:7590 z-index:213.90 8. JASPAR Types:DNA、protein Location:Canada 网址:http://jaspar./ Citation:2924 z-index:204.68 9. FlyBase-Database of Drosophila Genes & Genomes Types:DNA、phenotype、RNA、standard,ontology and nomenclature Location:United States 网址:http:/// Citation:3836 z-index:159.83 10. RefSeq- Reference Sequence databases Types:DNA、protein、RNA Location:United States 网址:http://www.ncbi.nlm./refseq/ Citation:6794 z-index:154.75 药物与化合物类1. NCBI-National Center for Biotechnology Information Types:disease、DNA、drug and chemical compound、基因表达、literature、metadata、phenotype、protein、RNA、standard,ontology and nomenclature Location:United States 网址:http://www.ncbi.nlm./ Citation:16174 z-index:359.42 2. DrugBank-Open Data Drug and Drug Target Database Types:drug and chemical compound Location:Canada 网址:http://www./ Citation:3839 z-index:319.92 3. ChEMBL Types:drug and chemical compound、interaction and network、protein Location:United Kingdom 网址:https://www./chembl/ Citation:1746 z-index:209.52 4. STITCH-Search Tool for Interacting Chemicals Types:drug and chemical compound、interaction and network、protein Location:Germany 网址:http://stitch./ Citation:624 z-index:62.40 Types:drug and chemical compound、interaction and network、protein、structure Location:United States 网址:http://www./bind/index.jsp Citation:706 z-index:62.26 6. CARD-The Comprehensive Antibiotic Rresistance database Types:drug and chemical compound Location:Canada 网址:http://arpcard./ Citation:286 z-index:47.48 7. TTD-Therapeutic Target Database Types:disease、drug and chemical compound Location:Singapore 网址:http://bidd./group/ttd/ttd.asp Citation:232 z-index:37.89 8. ChEBI-Chemical Entities of Biological Interest Types:drug and chemical compound、standard,ontology and nomenclature Location:United Kingdom 网址:http://www./chebi/ Citation:187 z-index:37.40 9. PubChem Types:drug and chemical compound、structure Location:United States 网址:https://pubchem.ncbi.nlm./ Citation:1412 z-index:32.95 10. GDSC- Genomics of Drug Sensitivity inCancer Types:disease、drug and chemical compound Location:United Kingdom 网址:http://www./ Citation:114 z-index:20.75 相互作用与网络类1. SRTING-Known and Predicted Protein-Protein Interactions Types:interaction and network、protein Location:Switzerland 网址:http:/// Citation:9248 z-index:513.78 2. BioGRID-Biological General Repository forInteraction Datasets Types:interaction and network、modification、protein Location:Canada 网址:http:/// Citation:4359 z-index:286.97 3. TRANDFAC-a database on transcription factors and their DNA binding sites Types:DNA、基因表达、interaction and network、protein、RNA Location:Germany 网址:http://www./pub/databases.html Citation:7590 z-index:213.90 4. SGD-Saccharomyces Genome Database Types:DNA、基因表达、interaction and network、protein Location:United States 网址:http://www./ Citation:772 z-index:128.67 5. miRTarBase-miRNA Target Database Types:基因表达、interaction and network、RNA Location:Taiwan 网址:http://mirtarbase.mbc./ Citation:899 z-index:128.43 Types:DNA、基因表达、interaction and network、phenotype、protein、RNA Location:Canada 网址:http://www./ Citation:2150 z-index:126.47 7. DIANA-TarBase- DIANA-TarBase Types:interaction and network、RNA Location:Greece 网址:http://diana.imis./DianaTools Citation:1513 z-index:126.08 8. BRENDA-The Comprehensive Enzyme Information System Types:interaction and network、protein、structure Location:Germany 网址:http://www./ Citation:706 z-index:99.85 9. CTD-Comparative Toxicogenomics Database Types:disease、interaction and network Location:United States 网址:http:/// Citation:1016 z-index:67.73 10. TEASTRACT- Yeast Search for TranscriptionalRegulators And Consensus Tracking Types:DNA、interaction and network、protein Location:Portugal 网址:http://www./ Citation:793 z-index:65.42 代谢与信号通路类1. KEGG -Kyoto Encyclopedia of Genes and Genomes Types:metabolic and signaling pathway、standard,ontology and nomenclature Location:Japan 网址:http://www./ Citation:25114 z-index:1321.79 2. HMDB -The Human Metabolome Database Types:metabolic and signaling pathway、protein Location:Canada 网址:http://www./ Citation:2615 z-index:235.35 3. Reactome- A Curated Pathway Database Types:metabolic and signaling pathway Location:United States 网址:http://www./ Citation:615 z-index:119.92 Types:metabolic and signaling pathway、modification Location:United States 网址:http://www./ Citation:653 z-index:108.83 5. EcoCyc- BioCyc Database Dollection Types:metabolic and signaling pathway Location:United States 网址:http:/// Citation:3517 z-index:67.14 6. APD -Antimicrobial Peptide Database Types:metabolic and signaling pathway、modification、protein、structure Location:United States 网址:http://aps./AP/main.php Citation:572 z-index:62.28 7. REBASE-The Restriction Enzyme Database Types:DNA、metabolic and signaling pathway、protein Location:United States 网址:http://rebase./ Citation:927 z-index:61.80 8. PathwayCommons - Search and visualize public biological pathway information Types:interaction and network、metabolic and signaling pathway Location:United States 网址:http://www./about/ Citation:395 z-index:56.43 9. PID -Patheay Interaction Database Types:metabolic and signaling Location:United States 网址:http://pid.nci./ Citation:593 z-index:56.43 10. TAIR - The Arabidopsis Information Resource Types:DNA、基因表达、interaction and network、literature、metabolic and signaling pathway、phenotype、protein、RNA、standard,ontology and nomenclature Location:United States 网址:https://www./ Citation:768 z-index:47.62 蛋白质类1. UniProt- The Universal Protein Resource Types:protein Location:United kingdom 网址:http://www./ Citation:13605 z-index:962.07 2. Pfam -Protein Families Database Types:protein、structure Location:United kingdom 网址:http://pfam./ Citation:19906 z-index:947.90 Types:DNA、protein、RNA Location:United kingdom 网址:http://www./ Citation:12662 z-index:775.55 4. STRING- Known and Predicted Protein-Protein Iinteractions Types:interaction and network、protein Location:Switzerland 网址:http:/// Citation:9248 z-index:513.78 5. UCSCGenome Browser - University of California,Santa Cruz Genome Browser Types:DNA、基因表达、protein、RNA Location:United States 网址:http://genome./ Citation:6429 z-index:428.60 6. NCBI -National Center for Biotechnology Information Types:disease、DNA、drug and chemical compound、基因表达、literature、metadata、phenotype、protein、RNA、standard,ontology and nomenclature Location:United States 网址:http://www.ncbi.nlm./ Citation:16174 z-index:359.42 7. PROSITE- Database of protein domains,families and functional sites Types:protein Location:Switzerland 网址:http://prosite./ Citation:8754 z-index:288.56 8. BioGRID- Biological General Repository for Interaction Datasets Types:interaction and network、modification、protein Location:Canada 网址:http:/// Citation:4359 z-index:286.97 9. InterPro- Protein sequence analysis & classification Types:protein Location:United kingdom 网址:http://www./interpro/ Citation:5033 z-index:279.61 Types:protein、standard,ontology and nomenclature Location:United kingdom 网址:http://www./ Citation:1059 z-index:246.22 RNA类Types:RNA、standard,ontology and nomenclature Location:United kingdom 网址:http://www./ Citation:11326 z-index:792.82 Types:DNA、protein、RNA Location:United kingdom 网址:http://www./ Citation:12662 z-index:775.55 3. RDP -Ribosomal Database Project Types:RNA Location:United States 网址:http://rdp.cme./ Citation:11954 z-index:433.89 4. UCSCGenomes Browser - University of California,Santa Cruz Genome Browser Types:DNA、基因表达、protein、RNA Location:United States 网址:http://genome./ Citation:6429 z-index:428.60 5. NCBI -National Center for Biotechnology Information Types:disease、DNA、drug and chemical compound、基因表达、literature、metadata、phenotype、protein、RNA、standard,ontology and nomenclature Location:United States 网址:http://www.ncbi.nlm./ Citation:16174 z-index:359.42 Types:RNA Location:United kingdom 网址:http://rfam./ Citation:3329 z-index:221.93 7. TRANSFAC- a database on transcription factors and their DNA binding sites Types:DNA、express、interaction and network、protein、RNA Location:Germany 网址:http://www./pub/databases.html Citation:7590 z-index:213.90 8. FlyBase- Database of Drosophila Genes & Genomes Types:DNA、protein、RNA Location:United States 网址:http:/// Citation:3836 z-index:159.83 9. RefSeq- Reference Sequence Database Types:DNA、protein、RNA Location:United States 网址:http://www.ncbi.nlm./refseq/ Citation:6794 z-index:154.75 10. miRTarBase - miRNA Target Database Types:基因表达、interaction and network、RNA Location:Taiwan 网址:http://mirtarbase.mbc./ Citation:899 z-index:128.43 结构类1. Pfam -Protein Families Database Types:protein、structure Location:United kingdom 网址:http://pfam./ Citation:19906 z-index:947.90 2. ChEMBL Types:drug and chemical compound、protein、structure Location:United kingdom 网址:https://www./chembl/ Citation:1746 z-index:209.52 3. CDD -Conserved Domain Database Types:protein、structure Location:United States 网址:http://www.ncbi.nlm./Structure/cdd/cdd.shtml Citation:4407 z-index:200.76 4. SWISS-MODEL- The SWISS-MODEL Repository Types:protein、structure Location:Switzerland 网址:http://swissmodel./repository/ Citation:7583 z-index:146.24 5. CAZy -Carbohydrate-active Enzymes Database Types:protein、structure Location:France 网址:http://www./ Citation:553 z-index:138.25 6. BRENDA- The Comprehensive Enzyme Information System Types:interaction and network、protein、structure Location:Germany 网址:http://www./ Citation:706 z-index:99.85 7. CATH Types:protein、structure Location:United kingdom 网址:http://www./ Citation:1488 z-index:97.22 8. RCSBPDB - RCSB Protein Data Bank Types:structure Location:United States 网址:http:/// Citation:853 z-index:91.64 9. DisProt- Database of Protein Disorder Types:protein、structure Location:United States 网址:http://www./ Citation:838 z-index:63.82 10. BMRB - biological magnetic resonance databank Types:DNA、protein、structure Location:United States 网址:http://www.bmrb./ Citation:635 z-index:63.50 爱菩新医药专注于提供生物医药信息服务,现有产品包括: 4)爱菩新药物靶点预测系统(即将上线) 此外,公司亦提供科研信息定制化服务,包括样品库存、试剂管理、生物医药研发数据管理、中医药数据管理。 |
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