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干货——常用医药数据库

 乐正叶齐 2018-12-25

       几十年前,医药研发人员查询相关数据,囊萤映雪,一本本书一篇篇文献地浏览。如今身处互联网时代,拿出手机一键查询,知晓天下事,医药研发数据也悉数获知。

       医药领域信息广阔,从药物设计到合成再到活性试验,从临床前到临床试验再到批准上市,从药品到医疗器械,从患者到医生等等,相关的医药数据库可多达成百上千个。对于医药研发人员而言,有价值的医药数据库大大提升他们的工作效率,也在一定程度上避免资源浪费。然而不少医药数据库为商业数据库,每年收费几十万到上百万不等,大部分医药研发人员望而却步。不过,市场上仍有大部分学术型医药数据库是免费的,小编今天就为大家献上常用的医药数据库,附上各常用医药数据库的引用次数及z-index。

疾病类​

1.    NCBI - National Center for BiotechnologyInformation

Types:disease、DNA、drug and chemical compound、基因表达、literature、metadata、phenotype、protein、RNA、standard,ontology and nomenclature

LocationUnited States

网址:http://www.ncbi.nlm./

Citation16174

z-index359.42

2.      COSMIC-Catalogue Of Somatic Mutations In Cancer

Types:disease、DNA

LocationUnited Kingdom

网址:http://cancer.

Citation4018

z-index261.1 

3.      MGD-Mouse Genome Database

Types:disease、DNA、基因表达、phenotype

LocationUnited States

网址:http://www.informatics./

Citation2658

z-index126.57

4.      HGMD-The Human Gene Mutation Database

Types:disease、DNA

LocationUnited Kingdom

网址:http://www.

Citation2655

z-index123.90

5.      HPO-Human Phenotype Ontology

Types:disease、phenotype

LocationUnited States

网址:http://www./

Citation975

z-index97.50

6.      CTD-Comparative Ttoxicogenomics Database

Types:disease、interaction and network

LocationUnited States

网址:http:///

Citation1016

z-index67.73

7.      Atlasof Genetics and Cytogenetics in Oncology and Haematolog

Types:disease、DNA

网址:http:///

LocationFrance

Citation1188

z-index66.00

8.      miR2Disease-miR-Disease

Types:disease、RNA

LocationChina

网址:http://www./

Citation537

z-index59.67

9.      PlasmoDB-Plasmodium Genomics Resourse

Types:disease、DNA、metabolic and signaling pathway

LocationUnited States

网址:http:///plasmo/

Citation413

z-index45.89

10.  DO-Disease Ontology

Types:disease、standard ontology and nomenclature

LocationUnited States

网址:http://www./

Citation248

z-index40.92

DNA类

1.Ensembl- Ensembl

Types:DNA、protein、RNA

LocationUnited Kingdom

网址:http://www./

Citation12662

z-index775.55

2.GenBank- GenBank

Types:DNA

LocationUnited States

网址:http://www.ncbi.nlm./genbank/

Citation46415

z-index576.67

3.      GWASCatalog

Types:DNA、phenotype

LocationUnited Kingdom

网址:http://www./gwas/

Citation3886

z-index431.78

4.      UCSCGenome Browser- University of California,Santa Cruz Genome Browser

Types:DNA、基因表达、protein、RNA

LocationUnited States

网址:http://genome./

Citation6429

z-index428.60

5.      NCBI-National Center for Biotechnology Information

Types:disease、DNA、drug and chemical compound、基因表达、literature、metadata、phenotype、protein、RNA、standard,ontology and nomenclature

LocationUnited States

网址:http://www.ncbi.nlm./

Citation16174

z-index356.42

6.      COSMIC-Catalogue of Somatic Mutations in Cancer

Types:disease、DNA

LocationUnited Kingdom

网址:http://cancer./

Citation4018

z-index261.17

7.      TRANSFAC-a database on transcription factors and their DNA binding sites

Types:DNA、基因表达、interaction and network、protein、RNA

LocationGermany

网址:http://www./pub/databases.html

Citation7590

z-index213.90

8.      JASPAR

Types:DNA、protein

LocationCanada

网址:http://jaspar./

Citation2924

z-index204.68

9.      FlyBase-Database of Drosophila Genes & Genomes

Types:DNA、phenotype、RNA、standard,ontology and nomenclature

LocationUnited States

网址:http:///

Citation3836

z-index159.83

10.  RefSeq- Reference Sequence databases

Types:DNA、protein、RNA

LocationUnited States

网址:http://www.ncbi.nlm./refseq/

Citation6794

z-index154.75

药物与化合物类

1.      NCBI-National Center for Biotechnology Information

Types:disease、DNA、drug and chemical compound、基因表达、literature、metadata、phenotype、protein、RNA、standard,ontology and nomenclature

LocationUnited States

网址:http://www.ncbi.nlm./

Citation16174

z-index359.42

2.      DrugBank-Open Data Drug and Drug Target Database

Types:drug and chemical compound

LocationCanada

网址:http://www./

Citation3839

z-index319.92

3.      ChEMBL

Types:drug and chemical compound、interaction and network、protein

LocationUnited Kingdom

网址:https://www./chembl/

Citation1746

z-index209.52

4.      STITCH-Search Tool for Interacting Chemicals

Types:drug and chemical compound、interaction and network、protein

LocationGermany

网址:http://stitch./

Citation624

z-index62.40

5.      BindingDB-BindingDB

Types:drug and chemical compound、interaction and network、protein、structure

LocationUnited States

网址:http://www./bind/index.jsp

Citation706

z-index62.26

6.      CARD-The Comprehensive Antibiotic Rresistance database

Types:drug and chemical compound

LocationCanada

网址:http://arpcard./

Citation286

z-index47.48

7.      TTD-Therapeutic Target Database

Types:disease、drug and chemical compound

LocationSingapore

网址:http://bidd./group/ttd/ttd.asp

Citation232

z-index37.89

8.      ChEBI-Chemical Entities of Biological Interest

Types:drug and chemical compound、standard,ontology and nomenclature

LocationUnited Kingdom

网址:http://www./chebi/

Citation187

z-index37.40

9.      PubChem

Types:drug and chemical compound、structure

LocationUnited States

网址:https://pubchem.ncbi.nlm./

Citation1412

z-index32.95

10.  GDSC- Genomics of Drug Sensitivity inCancer

Types:disease、drug and chemical compound

LocationUnited Kingdom

网址:http://www./

Citation114

z-index20.75

相互作用与网络类

1.      SRTING-Known and Predicted Protein-Protein Interactions

Types:interaction and network、protein

LocationSwitzerland

网址:http:///

Citation9248

z-index513.78

2.      BioGRID-Biological General Repository forInteraction Datasets

Types:interaction and network、modification、protein

LocationCanada

网址:http:///

Citation4359

z-index286.97

3.      TRANDFAC-a database on transcription factors and their DNA binding sites

Types:DNA、基因表达、interaction and network、protein、RNA

LocationGermany

网址:http://www./pub/databases.html

Citation7590

z-index213.90

4.      SGD-Saccharomyces Genome Database

Types:DNA、基因表达、interaction and network、protein

LocationUnited States

网址:http://www./

Citation772

z-index128.67

5.      miRTarBase-miRNA Target Database

Types:基因表达、interaction and network、RNA

LocationTaiwan

网址:http://mirtarbase.mbc./

Citation899

z-index128.43

6.      WornBase-WornBase

Types:DNA、基因表达、interaction and network、phenotype、protein、RNA

LocationCanada

网址:http://www./

Citation2150

z-index126.47

7.      DIANA-TarBase- DIANA-TarBase

Types:interaction and network、RNA

LocationGreece

网址:http://diana.imis./DianaTools

Citation1513

z-index126.08

8.      BRENDA-The Comprehensive Enzyme Information System

Types:interaction and network、protein、structure

LocationGermany

网址:http://www./

Citation706

z-index99.85

9.      CTD-Comparative Toxicogenomics Database

Types:disease、interaction and network

LocationUnited States

网址:http:///

Citation1016

z-index67.73

10.  TEASTRACT- Yeast Search for TranscriptionalRegulators And Consensus Tracking

Types:DNA、interaction and network、protein

LocationPortugal

网址:http://www./

Citation793

z-index65.42

代谢与信号通路类

1.      KEGG -Kyoto Encyclopedia of Genes and Genomes

Types:metabolic and signaling pathway、standard,ontology and nomenclature

LocationJapan

网址:http://www./

Citation25114

z-index1321.79

2.      HMDB -The Human Metabolome Database

Types:metabolic and signaling pathway、protein

LocationCanada

网址:http://www./

Citation2615

z-index235.35

3.      Reactome- A Curated Pathway Database

Types:metabolic and signaling pathway

LocationUnited States

网址:http://www./

Citation615

z-index119.92

4.      PhosphoSitePlus

Types:metabolic and signaling pathway、modification

LocationUnited States

网址:http://www./

Citation653

z-index108.83

5.      EcoCyc- BioCyc Database Dollection

Types:metabolic and signaling pathway

LocationUnited States

网址:http:///

Citation3517

z-index67.14

6.      APD -Antimicrobial Peptide Database

Types:metabolic and signaling pathway、modification、protein、structure

LocationUnited States

网址:http://aps./AP/main.php

Citation572

z-index62.28

7.      REBASE-The Restriction Enzyme Database

Types:DNA、metabolic and signaling pathway、protein

LocationUnited States

网址:http://rebase./

Citation927

z-index61.80

8.      PathwayCommons - Search and visualize public biological pathway information

Types:interaction and network、metabolic and signaling pathway

LocationUnited States

网址:http://www./about/

Citation395

z-index56.43

9.      PID -Patheay Interaction Database

Types:metabolic and signaling

LocationUnited States

网址:http://pid.nci./

Citation593

z-index56.43

10.  TAIR - The Arabidopsis Information Resource

Types:DNA、基因表达、interaction and network、literature、metabolic and signaling pathway、phenotype、protein、RNA、standard,ontology and nomenclature

LocationUnited States

网址:https://www./

Citation768

z-index47.62

蛋白质类

1.      UniProt- The Universal Protein Resource

Types:protein

LocationUnited kingdom

网址:http://www./

Citation13605

z-index962.07

2.      Pfam -Protein Families Database

Types:protein、structure

LocationUnited kingdom

网址:http://pfam./

Citation19906

z-index947.90

3.      Ensembl- Ensembl

Types:DNA、protein、RNA

LocationUnited kingdom

网址:http://www./

Citation12662

z-index775.55

4.      STRING- Known and Predicted Protein-Protein Iinteractions

Types:interaction and network、protein

LocationSwitzerland

网址:http:///

Citation9248

z-index513.78

5.      UCSCGenome Browser - University of California,Santa Cruz Genome Browser

Types:DNA、基因表达、protein、RNA

LocationUnited States

网址:http://genome./

Citation6429

z-index428.60

6.      NCBI -National Center for Biotechnology Information

Types:disease、DNA、drug and chemical compound、基因表达、literature、metadata、phenotype、protein、RNA、standard,ontology and nomenclature

LocationUnited States

网址:http://www.ncbi.nlm./

Citation16174

z-index359.42

7.      PROSITE- Database of protein domains,families and functional sites

Types:protein

LocationSwitzerland

网址:http://prosite./

Citation8754

z-index288.56

8.      BioGRID- Biological General Repository for Interaction Datasets

Types:interaction and network、modification、protein

LocationCanada

网址:http:///

Citation4359

z-index286.97

9.      InterPro- Protein sequence analysis & classification

Types:protein

LocationUnited kingdom

网址:http://www./interpro/

Citation5033

z-index279.61

10.  PX - ProteomeXchange

Types:protein、standard,ontology and nomenclature

LocationUnited kingdom

网址:http://www./

Citation1059

z-index246.22

RNA类

1.      miRBase- microRNA database

Types:RNA、standard,ontology and nomenclature

LocationUnited kingdom

网址:http://www./

Citation11326

z-index792.82

2.      Ensembl- Ensembl

Types:DNA、protein、RNA

LocationUnited kingdom

网址:http://www./

Citation12662

z-index775.55

3.      RDP -Ribosomal Database Project

Types:RNA

LocationUnited States

网址:http://rdp.cme./

Citation11954

z-index433.89

4.      UCSCGenomes Browser - University of California,Santa Cruz Genome Browser

Types:DNA、基因表达、protein、RNA

LocationUnited States

网址:http://genome./

Citation6429

z-index428.60

5.      NCBI -National Center for Biotechnology Information

Types:disease、DNA、drug and chemical compound、基因表达、literature、metadata、phenotype、protein、RNA、standard,ontology and nomenclature

LocationUnited States

网址:http://www.ncbi.nlm./

Citation16174

z-index359.42

6.      Rfam -RNA Families

Types:RNA

LocationUnited kingdom

网址:http://rfam./

Citation3329

z-index221.93

7.      TRANSFAC- a database on transcription factors and their DNA binding sites

Types:DNA、express、interaction and network、protein、RNA

LocationGermany

网址:http://www./pub/databases.html

Citation7590

z-index213.90

8.      FlyBase- Database of Drosophila Genes & Genomes

Types:DNA、protein、RNA

LocationUnited States

网址:http:///

Citation3836

z-index159.83

9.      RefSeq- Reference Sequence Database

Types:DNA、protein、RNA

LocationUnited States

网址:http://www.ncbi.nlm./refseq/

Citation6794

z-index154.75

10.  miRTarBase - miRNA Target Database

Types:基因表达、interaction and network、RNA

LocationTaiwan

网址:http://mirtarbase.mbc./

Citation899

z-index128.43

结构类

1.      Pfam -Protein Families Database

Types:protein、structure

LocationUnited kingdom

网址:http://pfam./

Citation19906

z-index947.90

2.      ChEMBL

Types:drug and chemical compound、protein、structure

LocationUnited kingdom

网址:https://www./chembl/

Citation1746

z-index209.52

3.      CDD -Conserved Domain Database

Types:protein、structure

LocationUnited States

网址:http://www.ncbi.nlm./Structure/cdd/cdd.shtml

Citation4407

z-index200.76

4.      SWISS-MODEL- The SWISS-MODEL Repository

Types:protein、structure

LocationSwitzerland

网址:http://swissmodel./repository/

Citation7583

z-index146.24

5.      CAZy -Carbohydrate-active Enzymes Database

Types:protein、structure

LocationFrance

网址:http://www./

Citation553

z-index138.25

6.      BRENDA- The Comprehensive Enzyme Information System

Types:interaction and network、protein、structure

LocationGermany

网址:http://www./

Citation706

z-index99.85

7.      CATH

Types:protein、structure

LocationUnited kingdom

网址:http://www./

Citation1488

z-index97.22

8.      RCSBPDB - RCSB Protein Data Bank

Types:structure

LocationUnited States

网址:http:///

Citation853

z-index91.64

9.      DisProt- Database of Protein Disorder

Types:protein、structure

LocationUnited States

网址:http://www./

Citation838

z-index63.82

10.  BMRB - biological magnetic resonance databank

Types:DNA、protein、structure

LocationUnited States

网址:http://www.bmrb./

Citation635

z-index63.50


爱菩新医药专注于提供生物医药信息服务,现有产品包括:

1)爱菩新化学信息管理系统

2)ipmDraw结构编辑器

3)爱菩新药物筛选管理系统

4)爱菩新药物靶点预测系统(即将上线)

此外,公司亦提供科研信息定制化服务,包括样品库存、试剂管理、生物医药研发数据管理、中医药数据管理。

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