▲William G. Kaelin教授(左)、Peter J. Ratcliffe教授(中)、以及Gregg L. Semenza教授(右)(图片来源:参考资料[1]) 治疗贫血的创新疗法 ▲生物体感知氧气的通路示意图(图片来源:参考资料[2],Credit:Cassio Lynm) ▲部分HIF-PHI分子结构式(图片来源:Meodipt [Public domain]) 治疗癌症的创新疗法 结语 本文题图:Photo by Adam Baker, 'Nobel Prize Medal in Chemistry' CC BY 4.0 (https://www./photos/atbaker/8459286843), via Flickr 参考资料: [1] The Nobel Prize in Physiology or Medicine 2019, Retrieved October 7, 2019, from https://www./prizes/medicine/2019/summary/ [2] 2016 Albert Lasker Basic Medical Research Award: Oxygen sensing – an essential process for survival, Retrieved October 7, 2019, from http://www./awards/show/oxygen-sensing-essential-process-survival/ [3] Beck et al., (2018). Discovery of Molidustat (BAY 85-3934): A Small-Molecule Oral HIF-Prolyl Hydroxylase (HIF-PH) Inhibitor for the Treatment of Renal Anemia. ChemMedChem, DOI: 10.1002/cmdc.201700783 [4] Soni and Padwad, (2018). HIF-1 in cancer therapy: two decade long story of a transcription factor. Acta Oncologica, https:///10.1080/0284186X.2017.1301680 [5] Gossamer Bio. Retrieved October 7, 2019, from https://www./pipeline/pipeline-overview/ [6] FibroGen, Inc. Corporate Presentation. Retrieved October 7, 2019, from https://fibrogen./static-files/c82c7b58-d8d5-4567-93b6-0e85ac6b2105 [7] Akebia Therapeutics. Retrieved October 7, 2019, from https:///research-and-development/vadadustat.aspx [8] Yu et al., (2017). Development of Inhibitors Targeting Hypoxia-Inducible Factor 1 and 2 for Cancer Therapy. Yonsei Medical Journal, Doi: 10.3349/ymj.2017.58.3.489 [9] Xie et al., (2017). Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis. Nature Medicine, https:///10.1038/nm.4412 [10] Merck to Acquire Peloton Therapeutics, Bolstering Oncology Pipeline. Retrieved October 7, 2019, from https://investors./news/press-release-details/2019/Merck-to-Acquire-Peloton-Therapeutics-Bolstering-Oncology-Pipeline/default.aspx [11] GSK submits first regulatory application for daprodustat in Japan for patients with renal anaemia due to chronic kidney disease. Retrieved October 7, 2019, from https://www./en-gb/media/press-releases/gsk-submits-first-regulatory-application-for-daprodustat-in-japan-for-patients-with-renal-anaemia-due-to-chronic-kidney-disease/ [12] Wu et al., (2019). Evaluation of a locked nucleic acid form of antisense oligo targeting HIF-1α in advanced hepatocellular carcinoma. World J Clinical Oncology, doi: 10.5306/wjco.v10.i3.149 |
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