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Gut microbiome, liver immunology, and liver diseases 肠道微生物组、肝脏免疫和肝脏疾病 10.1038/s41423-020-00592-6 12-14, Review Abstract & Authors:展开 Abstract:收起
The gut microbiota is a complex and plastic consortium of microorganisms that are intricately connected with human physiology. The liver is a central immunological organ that is particularly enriched in innate immune cells and constantly exposed to circulating nutrients and endotoxins derived from the gut microbiota. The delicate interaction between the gut and liver prevents accidental immune activation against otherwise harmless antigens. Work on the interplay between the gut microbiota and liver has assisted in understanding the pathophysiology of various liver diseases. Of immense importance is the step from high-throughput sequencing (correlation) to mechanistic studies (causality) and therapeutic intervention. Here, we review the gut microbiota, liver immunology, and the interaction between the gut and liver. In addition, the impairment in the gut–liver axis found in various liver diseases is reviewed here, with an emphasis on alcohol-associated liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), and autoimmune liver disease (AILD). On the basis of growing evidence from these preclinical studies, we propose that the gut–liver axis paves the way for targeted therapeutic modalities for liver diseases.
First Authors:
Rui Wang,Ruqi Tang Correspondence Authors:
Xiong Ma,Bernd Schnabl,Herbert Tilg All Authors:
Rui Wang,Ruqi Tang,Bo Li,Xiong Ma,Bernd Schnabl,Herbert Tilg
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