|
肠道微生物群与人类的共多样化 10.1126/science.abm7759 09-15, Article Abstract & Authors:展开 Abstract:收起
The gut microbiomes of human populations worldwide have many core microbial species in common. However, within a species, some strains can show remarkable population specificity. The question is whether such specificity arises from a shared evolutionary history (codiversification) between humans and their microbes. To test for codiversification of host and microbiota, we analyzed paired gut metagenomes and human genomes for 1225 individuals in Europe, Asia, and Africa, including mothers and their children. Between and within countries, a parallel evolutionary history was evident for humans and their gut microbes. Moreover, species displaying the strongest codiversification independently evolved traits characteristic of host dependency, including reduced genomes and oxygen and temperature sensitivity. These findings all point to the importance of understanding the potential role of population-specific microbial strains in microbiome-mediated disease phenotypes.
First Authors:
Taichi A Suzuki,J Liam Fitzstevens
Correspondence Authors:
Ruth E Ley
All Authors:
Taichi A Suzuki,J Liam Fitzstevens,Victor T Schmidt,Hagay Enav,Kelsey E Huus,Mirabeau Mbong Ngwese,Anne Grießhammer,Anne Pfleiderer,Bayode R Adegbite,Jeannot F Zinsou,Meral Esen,Thirumalaisamy P Velavan,Ayola A Adegnika,Le Huu Song,Timothy D Spector,Amanda L Muehlbauer,NinaMarchi,Hyena Kang,Lisa Maier,Ran Blekhman,Laure Ségurel,GwangPyo Ko,Nicholas D Youngblut,Peter Kremsner,Ruth E Ley
|
