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A high-fiber diet synergizes with Prevotella copri and exacerbates rheumatoid arthritis
高纤维饮食与Prevotella copri协同作用，加重类风湿性关节炎 10.1038/s41423-022-00934-6 11-02, Article Abstract & Authors:展开 Abstract:收起
Both preclinical and established rheumatoid arthritis (RA) patients display alterations in the gut microbiome. Prevotella spp. are preferentially enriched in a subset of RA patients. Here, we isolated a Prevotella strain, P. copri RA, from the feces of RA patients and showed that colonization of P. copri RA exacerbated arthritis in a collagen-induced arthritis (CIA) model. With the presence of P. copri RA colonization, a high-fiber diet exacerbated arthritis via microbial alterations and intestinal inflammation. Colonization of P. copri together with a high-fiber diet enabled the digestion of complex fiber, which led to the overproduction of organic acids, including fumarate, succinate and short-chain fatty acids. Succinate promoted proinflammatory responses in macrophages, and supplementation with succinate exacerbated arthritis in the CIA model. Our findings highlight the importance of dysbiosis when evaluating the effects of dietary interventions on RA pathogenesis and provide new insight into dietary interventions or microbiome modifications to improve RA management.
First Authors:
Lingjuan Jiang,Mengmeng Shang,Shengnan Yu
Correspondence Authors:
Zhihua Liu,Xuan Zhang
All Authors:
Lingjuan Jiang,Mengmeng Shang,Shengnan Yu,Yudong Liu,Hui Zhang,Yangzhong Zhou,Min Wang,Tingting Wang,Hui Li,Zhihua Liu,Xuan Zhang
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