一、Ovarian fibroma 卵巢纤维瘤 Definition Ovarian fibroma is a benign stromal tumour composed of fibroblastic cells within a
variably collagenous stroma. 定义 卵巢纤维瘤是一种良性间质肿瘤，由成纤维细胞组成伴有不同程度间质胶原化。 ICD-O coding 8810/0 Fibroma NOS ICD-O编码 8810/0纤维瘤NOS Essential and desirable diagnostic criteria Essential: fascicles of bland fibromatous spindle cells in a
variably collagenous stroma. 必需和理想的诊断标准 必需:在不同程度的胶原间质中，温和的纤维瘤性梭形细胞呈束状排列。
Fig.1.76 A Ovarian fibroma. Fascicles of bland spindle
cells with hyalinized plaques. B Mitotically active cellular fibroma. Cellular fascicles
of mildly atypical spindle cells with mitoses. 图1.76 A卵巢纤维瘤。温和的梭形细胞束，伴有玻璃样变的间质斑块。B核分裂象活跃的富于细胞性纤维瘤。呈束状排列的轻度不典型梭形细胞伴有核分裂象。 二、Thecoma 卵泡膜细胞瘤 Definition Thecoma is an ovarian stromal tumour composed predominantly of cells resemblingtheca cells. 定义 卵泡膜细胞瘤是一种卵巢间质肿瘤，主要由类似卵泡膜细胞的细胞组成。 ICD-O coding 8600/0 Thecoma NOS ICD-O编码 8600/0 Thecoma NOS Essential and desirable diagnostic criteria Essential: predominant population of stromal cells with
bland ovoid to round nuclei with appreciable pale-grey cytoplasm. Desirable: reticulinsurrounding
individual cells; positivity for inhibin, calretinin, and other sex cord
markers 必需和理想的诊断标准 必需:主要为间质细胞，细胞核温和，呈卵圆形到圆形，胞质明显为浅灰色。 理想:网状纤维围绕单个细胞；inhibin、calretinin和其他性索标记物呈阳性。
Fig.1.77 Thecoma. A Typical thecoma showing diffuse growth
of tumour cells with indistinct cell membranes resulting in a syncytial appearançe. B Uniform
tumour cells with the characteristic pale-grey cytoplasm. Fig.1.77 卵泡膜细胞瘤。典型的卵泡膜细胞瘤，肿瘤细胞弥漫性生长，细胞膜不清，形成合胞体样外观。B肿瘤细胞均匀一致，具有特征性的浅灰色细胞质。 三、Luteinized thecoma associated with sclerosing peritonitis 黄素化卵泡膜细胞瘤合并硬化性腹膜炎 Definition Luteinized thecoma associated with sclerosing peritonitis
is a distinctive ovarian stromal tumour typically associated with sclerosingperitonitis. 定义 黄素化卵泡膜细胞瘤合并硬化性腹膜炎是一种独特的卵巢间质肿瘤，通常与硬化性腹膜炎相关。 ICD-O coding 8601/0 Thecoma, luteinized ICD-O编码 8601/0黄素化卵泡膜细胞瘤 Essential and desirable diagnostic criteria Essential: cellular spindle cell proliferation with
luteinized or weakly luteinized cells. 必需和理想的诊断标准 必需:富于细胞的梭形细胞增生，伴黄素化或轻度黄素化。
Fig.1.78 Luteinized thecoma associated with sclerosing
peritonitis. A densely cellular area (top left) transitions abruptly to
an area of marked oedema (bottom right). Nests
of weakly luteinized cells are more
apparent in the oedematous area but are present throughout the image. 图1.78黄素化卵泡膜细胞瘤合并硬化性腹膜炎 密集的富于细胞区(左上)突然转变为明显的水肿区(右下)。在整个图像中可以看到，轻度黄素化细胞巢在水肿区更明显。 四、Sclerosing stromal tumour 硬化性间质瘤 Definition Sclerosing stromal tumour is a benign stromal neoplasm composed of cellular nodules with an admixture of epithelioid and spindled cells, separated byoedematous to collagenous stroma. 定义 硬化性间质瘤是一种良性间质肿瘤，由细胞结节与上皮样细胞和梭形细胞混合组成，被水肿和胶原化间质分隔。 ICD-O coding 8602/0 Sclerosing stromal tumour ICD-O编码 8602/0硬化性间质瘤 Essential and desirable diagnostic criteria Essential: pseudolobuleswith
epithelioid and spindled cells; hypocellular oedematous, collagenous, or myxoid stroma; thin-walled
dilated vessels, often with a haemangiopericytoma-like appearance. 必需和理想的诊断标准 必需:由上皮样细胞和梭形细胞形成的假小叶；细胞稀疏的水肿区、胶原性或黏液样间质；薄壁扩张的血管，常表现为血管外皮细胞瘤样外观。
Fig. 1.79 Sclerosing stromal tumour. A Cellular
pseudolobules are present in an oedematous to collagenous stroma. B Cellular
lobules are composed of spindled and epithelioid cells with clear to eosinophilicvacuolated cytoplasm; thin and
dilated vessels are also present. 图1.79硬化性间质瘤。A水肿至胶原化间质中可见富于细胞的假小叶。B富于细胞的小叶由梭形和上皮样细胞组成，胞浆透明至嗜酸性空泡状;可见薄壁扩张的血管。 五、Microcystic stromal tumour 微囊性间质瘤 Definition Microcystic stromal tumour is an ovarian stromal tumour
characterized by a distinctive microcystic appearance. 定义 微囊性间质瘤是一种卵巢间质瘤，具有特征性的微囊结构。 ICD-O coding 8590/0 Microcystic stromal tumour ICD-O编码 8590/0微囊性间质瘤 Essential and desirable diagnostic criteria Essential: stromal neoplasm with variable microcystic
morphology. Desirable: diffuse nuclear β-catenin and cyclin D1
immunoreactivity; lack of expression of inhibin and calretinin. 必需和理想的诊断标准 必需:具有不同程度微囊形态的间质肿瘤。 理想:β-catenin弥漫性的核阳性和cyclin D1的免疫阳性;缺乏inhibin和calretinin的表达。
Fig.1.80 Microcystic stromal tumour. A Cellular islands with coalescing microcysts intersected
by bands of hyalinized stroma. B Rounded microcysts and ovoid cells with
intracytoplasmic vacuoles merge with the solid cellular component (upper left).
C There is diffuse nuclear and cytoplasmicβ-catenin immunoreactivity. D Diffuse
nuclear staining with cyclin D1. 图1.80微囊性间质瘤。 A 含有微囊结构的细胞岛与玻璃样变的间质交错排列。B圆形的微囊性结构和伴有胞浆内空泡的卵圆形细胞与实性细胞成分混合(左上)。C 免疫组化β-catenin弥漫的核浆阳性。D Cyclin D1弥漫核阳性。 六、Signet-ring stromal tumour 印戒样间质瘤 Definition Signet-ring stromal tumour is a benign stromal tumour
containing cells with signet-ring morphology in a background of fibromatous stroma. 定义 印戒样间质瘤是一种良性间质肿瘤，在纤维瘤样间质的背景中，细胞呈印戒样形态。 ICD-O coding 8590/0 Signet-ring stromal tumour ICD-O编码 8590/0印戒样间质瘤 Essential and desirable diagnostic criteria Essential: signet-ring cells within a background
fibromatous stroma; lack of expression of EMA; absence of intracytoplasmicmucin. 必需和理想的诊断标准 必需:纤维瘤样间质背景内有印戒样细胞;缺乏EMA表达;胞浆内无黏液。
Fig.1.81 Signet-ring stromal tumour. A Sheets of signet-ring cells are present within a fibromatousbackground.
B The tumour cells have bland eccentric nuclei with small nucleoli and abundant
clear cytoplasm containing eosinophilic globules. 图1.81印戒样间质瘤。 A纤维瘤样背景内可见印戒样细胞片状分布。B肿瘤细胞核温和、核偏位，核仁小，胞质丰富，透明，含有嗜酸性小球。 七、Leydig cell tumour Leydig细胞瘤 Definition Leydig cell tumour is a benign steroid cell tumour confined
to or predominantly located in the ovarian hilus, which often contains
cytoplasmic Reinke crystals. 定义 Leydig细胞瘤是一种良性类固醇细胞肿瘤，局限于或主要位于卵巢门部，胞质内常含有Reinke结晶。 ICD-O coding 8650/0 Leydig cell tumour of the ovary NOS ICD-O编码 8650/0 Leydig细胞瘤，非特指型 Essential and desirable diagnostic criteria Essential: well-circumscribed tumour centred in the
ovarian hilus, consisting of bland steroid cells. Desirable: cytoplasmic Reinke crystals. 必需和理想的诊断标准 必需:以卵巢门为中心的边界清楚的肿瘤，由温和的类固醇细胞组成。 理想:胞质内Reinke晶体。
Fig. 1.82 Leydig cell tumour. The tumour is composed of
epithelioid cells with prominent nucleoli, abundant eosinophilic cytoplasm, andfibrinoid material within vessel wall. 图1.82 Leydig细胞瘤。肿瘤由上皮样细胞组成，核仁突出，有丰富的嗜酸性胞质，血管壁内纤维素样物沉积。
Fig.1.83 Ovarian Leydig cell tumour. The tumour cells have
abundant eosinophilic cytoplasm with easily identifiable cytoplasmic Reinke
crystals. 图1.83卵巢Leydig细胞瘤。肿瘤细胞有丰富的嗜酸性胞质，胞浆内易于识别的Reinke结晶。 八、Steroid cell tumour 类固醇细胞瘤 Definition Steroid cell tumour is an
ovarian parenchymal tumour composed of steroid cells. 定义 类固醇细胞瘤是一种由类固醇细胞组成的卵巢实质肿瘤。 ICD-O coding 86700 Steroid cell tumour Nos 8670/3 Steroid cell tumour, malignant ICD-O编码 86700类固醇细胞瘤Nos 8670/3类固醇细胞瘤，恶性 Essential and desirable diagnostic criteria Essential: a tumour consisting entirely of cells with
steroidsecreting morphology involving the ovarian parenchyma. Desirable: positive immunohistochemical staining for inhibin and other sex cord markers. 必需和理想的诊断标准 必需:一种涉及卵巢实质的完全由具有类固醇分泌形态的细胞组成的肿瘤。 理想: inhibin和其他性索标记物免疫组化染色阳性。
Fig. 1.84 Steroid cell tumour. A Low power of ovarian
steroid cell tumour composed of nests of cells with abundant eosinophilic cytoplasm. B The
tumour is composed of cells with abundanteosinophilic cytoplasm,
exhibitingdiffuse and follicle-likearchitecture.
C Diffuse cytoplasmic immunoreactivity for inhibin. 图1.84类固醇细胞瘤。A在低倍镜下，卵巢类固醇细胞瘤由富含嗜酸性细胞质的细胞巢组成。B肿瘤由富含嗜酸性细胞质的细胞组成，呈弥漫、滤泡样结构。C 免疫组化inhibin胞质弥漫阳性。 九、Ovarian fibrosarcoma 卵巢纤维肉瘤 Definition Ovarian fibrosarcoma is a malignant fibroblastic tumour of the ovary. 定义 卵巢纤维肉瘤是卵巢的一种恶性纤维母细胞肿瘤。 ICD-O coding 8810/3 Fibrosarcoma Nos ICD-O编码 8810/3纤维肉瘤 Nos Essential and desirable diagnostic criteria Essential: an overtly malignant
fibroblastic neoplasm. 必需和理想的诊断标准 必需:明显恶性的纤维母细胞肿瘤。
Fig. 1.85 Ovarian fibrosarcoma. Markedly atypical spindle
cells with numerous mitoses. 图1.85卵巢纤维肉瘤。显著异型的梭形细胞，伴有大量的核分裂象。 整理：南瓜子儿 审核：樊月 设计：鹏飞 编辑：雅芸 |
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