2023 年诺贝尔生理学或医学奖授予 mRNA 研究的两名科学家:卡塔林·卡里科(Katalin Karikó)德鲁·魏斯曼(Drew Weissman)两人分享奖金1100万瑞典克朗(约合732万人民币)奖金。 参考文献: [1] Karikó K, Ni H, Capodici J, et al. mRNA is an endogenous ligand for Toll-like receptor 3[J]. Journal of Biological Chemistry, 2004, 279(13): 12542-12550. [2] Karikó K, Buckstein M, Ni H, et al. Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA[J]. Immunity, 2005, 23(2): 165-175. [3] Dimitriadis G J. Translation of rabbit globin mRNA introduced by liposomes into mouse lymphocytes[J]. Nature, 1978, 274(5674): 923-924. [4] Zangi L, Lui K O, Von Gise A, et al. Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction[J]. Nature biotechnology, 2013, 31(10): 898-907. [5] Sahin U, Karikó K, Türeci Ö. mRNA-based therapeutics—develo** a new class of drugs[J]. Nature reviews Drug discovery, 2014, 13(10): 759-780. [6] Pardi N, Tuyishime S, Muramatsu H, et al. Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes[J]. Journal of Controlled Release, 2015, 217: 345-351. [7] Pardi N, Hogan M J, Pelc R S, et al. Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination[J]. Nature, 2017, 543(7644): 248-251. [8] Sahin U, Muik A, Derhovanessian E, et al. COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses[J]. Nature, 2020, 586(7830): 594-599. |
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