【每周三句半，一起读文献】小型皮质下卒中二级预防研究中的微出血

【每周三句半，一起读文献】

Microbleeds in the Secondary Prevention of Small Subcortical Strokes Trial: Stroke, Mortality, and Treatment Interactions

小型皮质下卒中二级预防研究中的微出血：卒中、死亡率和治疗相互作用

1. 例句：

Moreover, methodological limitations, imposed by observational design, small sample sizes, and/or absence of clear classification of stroke subtype, hamper our current understanding of CMBs in lacunar stroke and the independent contribution of CMBs to the aforementioned outcomes beyond simply marking underlying CSVD.

词汇：

• methodological：方法学的。 引申：methodology-方法学；method-方法。

• aforementioned：前述。

• beyond：远不止。引申： the back of beyond-极远的地方，天涯海角，穷乡僻壤。

句型：

此处，用“impose”一词已明确limitation的来源，而后半句则显示现有的方法学的“limitation”所带来的问题。

译文：

此外，由于观察性设计、小样本量和/或缺乏明确的卒中亚型的分类，造成了方法学上的限制，阻碍了我们目前对腔隙性卒中CMB的理解，以及CMB对上述结果的独立贡献，而不仅仅是发现潜在的CSVD。

2.  例句：

Eligible participants were randomly assigned, in a 2-by-2 factorial design, to both an antiplatelet intervention (1:1; aspirin 325mg plus clopidogrel 75mg vs aspirin 325mg plus placebo; double-blind) and a target level of systolic blood pressure control (1:1; lower [<130mmhg] vs="" higher="" [130–149mmhg];="" open="">

词汇：

• Eligible：合格的。引申：eligibility-合格性。

• Factorial：析因分析。

句型：

列个表来看看怎么个析因分析法吧：

译文：

有资格的参与者被随机分配，以2×2的析因设计，涉及到的因素有：抗血小板治疗（1:1；阿司匹林325mg +氯吡格雷75mg vs阿司匹林325mg +安慰剂；双盲）； 和收缩压控制目标水平(1:1；较低[< 130mmhg]vs更高[130="" -="">

3.  例句：

Conversely, CMBs were not predictive of all-cause mortality within our cohort, suggesting that underlying CSVD might have confounded their previously reported associations with mortality in broader populations

词汇：

• Conversely：相反的。引申： converse-逆行。

• Confounded： 混淆。引申： confounder-混杂因素。

译文：

相反，CMBs并不能预测我们的队列中的全因死亡率，这表明，潜在的CSVD可能会干扰他们既往报告的在更广泛人群中死亡率的相关性。

？你来翻译一句吧：

Importantly, the nonstandardization of GRE sequence acquisition parameters and the unavailability of data on these parameters or MRI field strengths, which were never captured, for inclusion into our multivariate analyses are major limitations that may have resulted in heterogeneous CMB detection rates across the various recruitment centers and confounded our results.

上期译文：

Suboptimal reduction of platelet aggregation by aspirin is a potential mechanism in selected patients. Although a modification of the antiplatelet regimen in such patients may be considered, uncertainty exists for optimal antiplatelet therapy after an ischemic stroke or TIA while on aspirin.

阿斯匹林对血小板聚集的减少处于不理想状态在经筛选的患者中存在一种潜在的机制。尽管在此类患者中需要考虑对抗血小板治疗方案进行了调整，但在服用阿司匹林时出现的缺血性脑卒中或TIA，此时何种为最优抗血小板治疗仍存在不确定性。

Shoamanesh A, Pearce LA, et al. Microbleeds in the Secondary Prevention of Small Subcortical Strokes Trial: Stroke, Mortality, and Treatment Interactions. ANN NEUROL 2017;82:196–207