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基金的申请呈指数增长的同时，文章的数量也在迅速增加，今天已经是12月7号了，离2018年只有不到一个月了，真正看一下才发现2017年发表的10分以上的文章也只有不到20篇，5分-10分杂志范围的文章不到60篇，确实是不多，所以说总体上速度增长较快，但总量还是偏少的。今天我们先看5-10分这个范围，这里我们来介绍两种常见的类型。
第一个类型是表达谱（Expression Profile/Pattern）的文章，就是这种： Microarray Expression Profile of Circular RNAs in Plasma from Primary Biliary Cholangitis Patients.Cell Physiol Biochem. 2017 Nov 29;44(4):1271-1281. Screening circular RNA expression patterns following focal cerebral ischemia in mice.Oncotarget. 2017 Sep 23;8(49):86535-86547. Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection.Oncotarget. 2017 Jul 5;8(47):81825-81837. Altered Circular RNA Expression in Patients with Repeated Implantation Failure.Cell Physiol Biochem. 2017 Nov 13;44(1):303-313. Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma.Cell Physiol Biochem. 2017;43(3):969-985. Screening differential circular RNA expression profiles reveals hsa_circ_0004018 is associated with hepatocellular carcinoma.Oncotarget. 2017 Apr 6;8(35):58405-58416. Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients.Cell Physiol Biochem. 2017;42(2):651-659. Circular RNA Expression Profiles Alter Significantly in Mouse Brain After Transient Focal Ischemia.Stroke. 2017 Sep;48(9):2541-2548.
文章主要集中在Oncotarget和Cell Physiol Biochem这两个杂志，最后一篇是Stroke杂志的，这7篇在OT和CPB杂志发表的都是咱们中国人，最后这个是印度的科学家： 
关于OT和CPB这两个杂志我们就不说啥了，只是对于最后一篇文章发在Stroke杂志上有点难以理解，咱们的分析图也不差啊： 
印度这篇Stroke杂志的图：
不太明白原因，大家可以留言告诉我们。
第二个类型就是circRNA吸附miRNA的文章，比如： Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients.Oncotarget. 2017 Aug 4;8(36):60280-60290. Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression.Mol Cancer. 2017 Sep 11;16(1):151. Circular RNA profiling reveals an abundant circLMO7 that regulates myoblasts differentiation and survival by sponging miR-378a-3p.Cell Death Dis. 2017 Oct 26;8(10):e3153. Increased circular RNA UBAP2 acts as a sponge of miR-143 to promote osteosarcoma progression.Oncotarget. 2017 Jun 27;8(37):61687-61697. Circular RNA MYLK as a competing endogenous RNA promotes bladder cancer progression through modulating VEGFA/VEGFR2 signaling pathway.Cancer Lett. 2017 Sep 10;403:305-317. circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family.Oncogene. 2017 Aug 10;36(32):4551-4561. Circular RNA ZNF609 functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-150-5p in Hirschsprung's disease.Oncotarget. 2017 Jan 3;8(1):808-818.
这个是比较经典的circRNA吸附miRNA从而调控靶基因和下游通路的模式： 
环状RNA的定位和分子功能
今年曹雪涛院士还发了一篇hepatology（曹雪涛院士：想发Hepatology没有那么难）：
需要说明的是，不是说这两种类型的研究就可以发5-10分，还有一些3-5分的杂志： Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271.Am J Cancer Res. 2017 Jul 1;7(7):1566-1576. CircFUT10 reduces proliferation and facilitates differentiation of myoblasts by sponging miR-133a.J Cell Physiol. 2017 Oct 18. Circular RNA expression profiles and features in human tissues: a study using RNA-seq data.BMC Genomics. 2017 Oct 3;18(Suppl 6):680. Comprehensive analysis of circRNA expression profiles in humans by RAISE.Int J Oncol. 2017 Dec;51(6):1625-1638.
好，今天内容就到这里，下次我们来介绍10分以上的文章里面研究circRNA的几个新角度，敬请期待！
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