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转自：中国风湿病公众论坛【整理编辑：时英平】 摘要：大量的临床证据表明应激性生活事件和自身免疫性疾病之间的联系表明压力可能在这些免疫紊乱性疾病的发病机制中起重要作用。在这篇文章中，我们讨论了压力的影响，不是对免疫系统，而是对特定的细胞群的自身免疫反应的作用。把干燥综合征作为一种自身免疫性疾病的模型，我们评价压力在自身免疫反应中的启动和持续作用。我们提供的数据揭示了压力对唾液腺上皮细胞的影响，表明压力可以通过对唾液腺上皮细胞的各种影响而成为免疫原。
附原文：Abstract A large body of clinical evidence on the association between stressful life events and autoimmune diseases suggests that stress may play an important role in the pathogenesis of these disorders. In this article, we discuss the effects of stress, not on the immune system but on specific cell populations against which the autoimmune reactivity is directed. Using Sjögren's syndrome as a model autoimmune disease, we review the role of stress in the initiation and perpetuation of autoimmune reactivity. We present data that reveal the effects of stress on salivary gland epithelial cells, suggesting that stress can become immunogenic through its various effects on salivary gland epithelium. This article is protected by copyright. All rights reserved.
引自：Skopouli FN et al. How stress contributes to autoimmunity: Lessons from Sjögren's syndrome (SS). FEBS Lett. 2017 Dec 9.
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