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研究回顾性分析了本中心411例TA患者，探索其肾动脉受累患者的临床特征。210例TA患者肾动脉受累，其中78.1%伴肾动脉狭窄。 与肾动脉未受累TA患者相比，肾动脉累及TA患者发病年龄较轻（23.5 vs 25.6岁），高血压发病率更高（74.6% vs 28.1%），更易发生充血性心率衰竭（22.4% vs 7.6%）、肺动脉高压（19.9% vs 9.5%）。随着肾动脉狭窄程度的加重，肾小球滤过率（eGFR）逐渐降低。 发病年龄大于24岁、病程超过19个月、肾动脉受累是TA患者肾功能受损的独立危险因素。与肾动脉未受累TA患者相比，肾动脉受累TA患者的心肾功能不全更严重。肾小球率过滤与肾动脉狭窄程度呈负相关。 原 文 The renal artery is involved in Chinese Takayasu's arteritis patients Abstract Takayasu's arteritis is a rare systemic vasculitis mainly affecting the aorta and its major branches. Previous studies have suggested that almost half of the Asian Takayasu's patients have renal artery involvement. However, due to the rarity of the disease, little is known about renal artery involvement in Chinese Takayasu's arteritis patients. Here, we retrospectively reviewed and analyzed 411 patients diagnosed with Takayasu's arteritis in our center to explore the clinical features of renal artery involvement in this group of patients. Of these, 201 patients were diagnosed to have renal artery involvement, with stenosis (78.1%) the most common renal artery pattern. Compared to those without, patients with renal artery involvement were significantly younger at disease onset (23.5 vs 25.6 years) and more frequently had hypertension (74.6% vs 28.1%). Congestive heart failure (22.4% vs 7.6%) and pulmonary hypertension (19.9% vs 9.5%) were both significantly more prevalent among patients with than those without renal artery involvement. The estimated glomerular filtration rate (eGFR) significantly decreased as the severity of renal artery stenosis increased. Age at disease onset older than 24 years (odds ratio 6.06 [95% Confidence Interval 2.76-13.3]), disease duration longer than 19 months (3.35 [1.52-7.4]) and renal artery involvement (8.7 [3.8-20.1]) were independent risk factors for renal dysfunction (eGFR under 90 mL/min/1.73m2) among patients with Takayasu's arteritis. Thus, patients with renal artery involvement have more severe cardiac and renal dysfunction compared to those without. The eGFR is correlated negatively with the severity of renal artery stenosis. KEYWORDS: Chinese; Takayasu’s arteritis; clinical features; renal artery involvement; renal function 译者：李治琴 西临床免疫科 来源：西京风湿免疫 |
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来自： 昵称36906134 > 《血管炎》
