来源:磁共振成像传媒 高翔, 彭如臣. IVIM对脑小血管病患者脑内微结构特性的研究. 磁共振成像, 2019, 10(9): 641-644. 彭如臣,首都医科大学附属北京潞河医院医学影像中心,硕士,主任医师,医学影像中心主任 教育背景:1990年毕业于河北医科大学 专业特长:(1)神经系统影像诊断;(2)呼吸系统影像诊断;(3)肌肉骨骼系统影像诊断; 获得奖励或荣誉称号:发表论文50余篇;主编著作1项;参编著作3项;2016年荣获北京市优秀共产党员、北京市通州区第三届“勤廉之星”;2018年荣获首都劳动奖章。 研究方向:(1)下肢血管CT及磁共振成像研究;(2)头颈部血管磁共振成像研究;(3)心血管磁共振成像研究。 社会兼职:北京医学会放射分会常务委员、首都医科大学医学影像学系委员、首都医科大学核医学学系委员、北京市通州区医学影像质控组组长、《磁共振成像》杂志审稿专家 腔隙性脑梗死的患者(32例)首次出现腔隙性梗死综合征,并同时在头颅磁共振成像中看到近期的皮层下梗死灶[7]。这些患者的排除标准包括潜在的心血管栓子来源(如房颤)、一侧或双侧颈内动脉狭窄超过50%。 排除所有具有脑血管病史、患其他中枢神经系统疾病或有磁共振成像禁忌证的参与者。记录一般资料,包括年龄、性别、学历、心血管风险因素(如高血压、高血脂及糖尿病)、吸烟史及身体质量指数。 但本研究仍有几点局限性。第一,IVIM可能会简化包括病态区域的实际结构,例如白质高信号区域。第二,本研究的IVIM图像只使用了一个方向,更多方向的图像能提供白质方向性的更多信息,但是多方向图像需要长时间扫描,病人舒适性降低,并有可能产生更多运动伪影。最后,轻度血管性认知障碍患者有可能是除了脑小血管病之外的病理导致,如阿尔茨海默病等神经退行性病变。为了尽可能避免干扰,笔者尝试只选择那些因脑小血管病而患有轻度血管性认知障碍的患者。这个确定标准综合考虑了患者病史、生化检查、神经心理评估及磁共振图像。此外,海马明显萎缩是阿尔茨海默病的特征性改变之一,磁共振图像显示海马萎缩的患者会被排除出去。 [1]Makin SD, Turpin S, Dennis MS, et al. 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