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编者按：最近，随着中国内陆宫颈癌疫苗获批上市，引发了公众越来越多的关注。宫颈癌疫苗即人类乳头瘤病毒（HPV）疫苗，HPV属于脱氧核糖核酸（DNA）病毒，除了可以引起子宫颈上皮癌，还涉及其他类型上皮癌。HPV对于乳腺癌发生的作用，近年来一直由于各个研究报告相互矛盾而存在争议。 2018年6月8日，欧洲乳腺癌专科学会《乳腺》在线发表意大利米兰大学欧洲肿瘤研究所、希腊雅典大学医学院安德烈亚斯塞格罗斯医院、圣萨瓦综合肿瘤医院的研究报告，通过现代DNA微阵列（DNA芯片）技术，确定了乳腺癌患者乳腺和宫颈的HPV感染发生率。 该前瞻研究入组乳腺癌患者201例，详细记录病史，并在手术期间无菌条件下，从肿瘤、健康邻近乳腺组织、阳性前哨淋巴结、宫颈采集标本，通过DNA微阵列技术，对所有标本分析了24种HPV的DNA。 结果发现，虽然所用技术灵敏度高，但是任何乳腺或淋巴结标本均未发现HPV。宫颈标本发现HPV阳性28例，根据分析表明，HPV阳性与阴性患者相比：
因此，根据该研究细致的标本采集，结合非常敏感的微阵列技术，表明HPV与乳腺癌无关。不过，宫颈标本HPV阳性患者的某些乳腺癌特征存在显著差异。 Breast. 2018 Jun 8;40:165-169. [Epub ahead of print] HPV infection and breast cancer. Results of a microarray approach. Andriana Kouloura, Electra Nicolaidou, Ioannis Misitzis, Euaggelia Panotopoulou, Vasilios Smyrniotis, Giovanni Corso, Paolo Veroneci, Nikolaos Arkadopoulos. European Institute of Oncology, Milan, Italy; National and Kapodistrian University of Athens School of Medicine, Andreas Syggros Hospital, Athens, Greece; Saint Savvas General Anticancer Hospital, Athens, Greece. OBJECTIVES: Human papilloma virus (HPV) has been implicated in several types of epithelial cancer. The role of HPV in breast carcinogenesis has been a matter of debate fueled by conflicting reports in recent years. The aim of this study is to identify the prevalence of breast and cervical HPV infection in cancer patients by using a modern microarray approach. MATERIALS AND METHODS: In the present prospective study, 201 breast cancer patients were included. For each patient a detailed medical history was taken and during the operation, under sterile conditions, samples were collected, from the tumour, the healthy adjacent breast tissue and any positive sentinel lymph nodes. In addition, for each patient a cervical sample was also collected. All samples were analysed for DNA of 24 types of HPV using a microarray technique. RESULTS: Despite the high sensitivity of the technique used, no HPV DNA was identified in any of the breast or lymph node samples. Our analysis showed that patients with HPV positive cervical samples (28 cases) were more likely to have tumors with positive progesterone receptors (p=0.041) and were also more likely to have two or three positive lymph nodes (p=0.002). CONCLUSION: In the present study, a combination of careful sample collection and a very sensitive microarray approach showed no correlation between HPV and breast cancer. However some characteristics of the breast tumors were different among patients with HPV DNA in their cervical samples. DOI: 10.1016/j.breast.2018.05.010 |
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