CEA 是临床医生耳熟能详的肿瘤标志物之一。在使用过程中,你是否产生过这样的疑问? 1、CEA 具体是什么? 2、什么时候 CEA 会增高? 3、CEA 的增高有什么意义? 图源:作者 图源:作者 参考文献: [1]Gold P, Freedman SO. Specific carcinoembryonic antigens of the human digestive system. J Exp Med. 1965a;122(3):467–81. [2]Gold P, Freedman SO. Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J Exp Med. 1965b;121:439–62. [3]Martin Jr EW, Kibbey WE, DiVecchia L, Anderson G, Catalano P, Minton JP. Carcinoembryonic antigen: clinical and historical aspects. Cancer. 1976;37(1):62–81. [4]Fritsche R, Mach JP. Isolation and characterization of carcinoembryonic antigen (CEA) extracted from normal human colon mucosa. Immunochemistry. 1977;14(2):119–27. [5]Engvall E, Shively JE, Wrann M. Isolation and characterization of the normal cross reacting antigen: homology of its NH2-terminal amino acid sequence with that of carcinoembryonic antigen. Proc Natl Acad Sci U S A. 1978;75(4):1670–4. [6]Chevinsky AH. CEA in tumors of other than colorectal origin. Semin Surg Oncol. 1991;7(3):162–6. [7] 肿瘤标志物临床手册 [M].: 人民军医出版社,2008.13-15. |
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