 现在有研究表明，肉类食物吃太少，罹患痴呆症的风险会提高，研究刊登在《阿尔茨海默病杂志》（Journal of Alzheimer's Disease）上。  法国蒙佩利尔大学（University of Montpellier, France）的研究团队，分析了来自3个城市，年龄在65岁及以上共5,934名志愿者的数据，并对他们的饮食习惯进行问卷调查，平均随访时间9.8年。研究结果发现，其中有622位参与者罹患了痴呆症，466位罹患阿尔茨海默病。 研究团队针对追踪结果表示，他们在分析饮食与痴呆症发病两者的关系后，发现每星期吃肉类食物1次以下的人，比每星期吃肉4次以上的人，罹患痴呆症的风险高出58%，而罹患阿尔茨海默病的风险更是提高了67%。  研究团队推估，因为吃太少肉而让痴呆风险提高的原因，可能和维生素B12摄取不足有关。美国有杂志曾经报导，美国塔夫斯大学（Tufts University）人类营养老化研究中心（Human Nutrition Research Center on Aging）科学家Jean Meyer发现，缺乏维生素B12的话，可能会引起血管性认知功能障碍。因此，为了降低痴呆风险，肉类食物还是得适量吃一些，但蔬菜水果也相当重要，必需营养均衡才健康。  Abstract Background: The links between diet and the risk of dementia have never been studied considering the possibility of protopathic bias (i.e., reverse causation). Objective: We aimed to examine the relationship between consumption frequency of meat, fish, fruits, and vegetables and long-term risk of dementia and Alzheimer's disease (AD), by taking into account this possibility. Methods: We analyzed data of 5,934 volunteers aged 65 and over from the Three-city study who were followed every 2 to 4 years for 12 years. Dietary habits were assessed at inclusion using a brief food frequency questionnaire. The presence of symptoms of dementia was investigated at each follow-up visit. To limit the risk of protopathic bias, a 4-year lag window between exposure and disease assessment was implemented by excluding from the analyses all dementia cases that occurred during the first four years after inclusion. Analyses were performed using a Cox proportional hazard model and were adjusted for socio-demographic, lifestyle, and health factors. Results: The average follow-up time was 9.8 years. During this period, 662 cases of dementia, including 466 of AD, were identified. After adjustment, only low meat consumption (≤1 time/week) was associated with an increased risk of dementia and AD compared with regular consumption (≥4 times/week) (HR=1.58 95% CI=[1.17-2.14], HR=1.67 95% CI=[1.18-2.37], respectively). No association was found between the consumption of fish, raw fruits, or cooked fruits and vegetables and the risk of dementia or AD. Conclusion: These findings suggest very low meat consumption increases the long-term risk of dementia and AD, and that a protopathic bias could have impacted finding from previous studies. 参考文献 Source： Intake of Meat, Fish, Fruits, and Vegetables and Long-Term Risk of Dementia and Alzheimer’s Disease Reference： Journal of Alzheimer's disease: JAD 68(2):1-12 · March 2019 DOI: 10.3233/JAD-180919 关爱父母 关注阿尔茨海默病 |
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