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Associations between high temperatures in pregnancy and risk of preterm birth, low birth weight, and stillbirths: systematic review and meta-analysis 孕期高温与早产、低出生体重及死胎的关联：系统综述和荟萃分析 10.1136/bmj.m3811 11-04, Article Abstract & Authors:展开 Abstract:收起
Objective : To assess whether exposure to high temperatures in pregnancy is associated with increased risk for preterm birth, low birth weight, and stillbirth.
Data sources: Medline and Web of Science searched up to September 2018, updated in August 2019.
Eligibility criteria for selecting studies: Clinical studies on associations between high environmental temperatures, and preterm birth, birth weight, and stillbirths.
Results : 14 880 records and 175 full text articles were screened. 70 studies were included, set in 27 countries, seven of which were countries with low or middle income. In 40 of 47 studies, preterm births were more common at higher than lower temperatures. Exposures were classified as heatwaves, 1°C increments, and temperature threshold cutoff points. In random effects meta-analysis, odds of a preterm birth rose 1.05-fold (95% confidence interval 1.03 to 1.07) per 1°C increase in temperature and 1.16-fold (1.10 to 1.23) during heatwaves. Higher temperature was associated with reduced birth weight in 18 of 28 studies, with considerable statistical heterogeneity. Eight studies on stillbirths all showed associations between temperature and stillbirth, with stillbirths increasing 1.05-fold (1.01 to 1.08) per 1°C rise in temperature. Associations between temperature and outcomes were largest among women in lower socioeconomic groups and at age extremes. The multiple temperature metrics and lag analyses limited comparison between studies and settings.
Conclusions : Although summary effect sizes are relatively small, heat exposures are common and the outcomes are important determinants of population health. Linkages between socioeconomic status and study outcomes suggest that risks might be largest in low and middle income countries. Temperature rises with global warming could have major implications for child health.
First Authors:
Matthew Francis Chersich Correspondence Authors:
Matthew Francis Chersich All Authors:
Matthew Francis Chersich,Minh Duc Pham,Ashtyn Area,Marjan Mosalam Haghighi,Albert Manyuch,Callum P Swift,Bianca Wernecke,Matthew Robinson,Robyn Hetem,Melanie Boeckmann,Shakoor Hajat,the Climate Change and Heat-Health Study Group
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