作者:上海细胞治疗集团 来源:上海细胞治疗集团 药时代获得授权转载。衷心感谢! 一、如何对抗实体肿瘤的微环境——在肿瘤微环境里面,CAR-T细胞会受到抑制发挥不了作用; 二、如何精准靶向肿瘤细胞——在血液肿瘤中,这些细胞会高度表达CD19,就像是指路明灯一样,带领CAR-T细胞瞄准,但是实体肿瘤中却依旧需要寻找这样的靶点。 《Nature Communications》:神经母细胞瘤CAR-T疗法新进展 “癌种之王”胰腺癌最常见分类,CAR-T细胞疗法发现新安全靶标 参考资料: 1.Preclinical assessment of the efficacy and specificity of GD2-B7H3 SynNotch CAR-T in metastatic neuroblastoma 2.CEACAM7 Is an Effective Target for CAR T-cell Therapy of Pancreatic Ductal Adenocarcinoma 3.Creating a safe CAR T-Cell therapy to fight solid tumors in children 4.Researchers identify novel target that could improve the safety of CAR T cell therapy for pancreatic cancer |
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