这一般是评价疫苗诱导的应答是偏向于Th1还是Th2型(为Th细胞的两个分化方向,Th1可以分泌多种细胞因子如干扰素促进CTL反应即所谓的细胞免疫倾向,而Th2则可以分泌细胞因子IL-4促进抗体产生即所谓的体液免疫倾向,当然这两种方向只是偏向而已) BALB/c mice typically
respond to vaccines and subunit vaccines with a Th2-type immune
response, which is associated with the stimulation of IgG1
antibodies . However, the major antibody isotype present in the
sera of mice that survive viral infections is IgG2a , which is
stimulated during Th1-type immune responses . Stimulation of IgG2a
antibodies has been associated with increased efficacy
of BALB/C鼠对疫苗的的典型应答是与IgG2a抗体相关的TH2型免疫应答。然而,存在于病毒感染的鼠血清中的主要抗体同种型是IgG2a抗体,是Th1 型免疫应答分泌的。刺激IgG2a抗体与疫苗的有效性正相关。另外,IgG2a单克隆抗体在清除病毒感染上比IgG1抗体更有效。 |
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