m-appid='wx1511803af5cdca8a' data-miniprogram-path='pages/userInfo?username=belb' data-miniprogram-nickname='丁香园丨医生交流' data-miniprogram-type='image' data-miniprogram-servicetype='' wah-hotarea='click' href=''> 思考: 文献复习: 诊治思路: 患者为老年男性,胸腺瘤切除术后反复肺炎,查体液免疫及 T、B 淋巴细胞免疫均存在缺陷,可确诊 Good 综合征。仔细询问病史及查体,本患者无重症肌无力表现。 总结: 参考文献 1. Bonilla FA, Khan DA, Ballas ZK, Chinen J, Frank MM, Hsu JT, et al. Practice parameter for the diagnosis and management of primary immunodeficiency. J Allergy Clin Immunol 2015;136:1186-1205.e1-78. doi: 10.1016/j.jaci.2015.04.049. 2. Shankar Kikkeri N, Beladakere Ramaswamy S, Bhagavan SM, Govindarajan R. Recurrent Opportunistic Infections in a Thymectomised Patient with Myasthenia Gravis and Good’s Syndrome. Cureus 2018;10:e3130. doi: 10.7759/cureus.3130. 3. Good RA. Absence of plasma cells from bone marrow and lymph nodes following antigenic stimulation in patients with a gamma globulinemia. Rev Hematol 1954;9:502–3. 4. Primary immunodeficiency diseases. Report of an IUIS Scientific Committee. International Union of Immunological Societies. Clin Exp Immunol 1999;118 Suppl 1:1–28. doi: 10.1046/j.1365-2249.1999.00109.x. 5. Malphettes M, Gérard L, Galicier L, Boutboul D, Asli B, Szalat R, et al. Good syndrome: an adult-onset immunodeficiency remarkable for its high incidence of invasive infections and autoimmune complications. Clin Infect Dis Off Publ Infect Dis Soc Am 2015;61:e13-19. doi: 10.1093/cid/civ269. 6. Holbro A, Jauch A, Lardinois D, Tzankov A, Dirnhofer S, Hess C. High prevalence of infections and autoimmunity in patients with thymoma. Hum Immunol 2012;73:287–90. doi: 10.1016/j.humimm.2011.12.022. 7. Kelleher P, Misbah SA. What is Good’s syndrome? Immunological abnormalities in patients with thymoma. J Clin Pathol 2003;56:12–6. doi: 10.1136/jcp.56.1.12. 8. Kelesidis T, Yang O. Good’s syndrome remains a mystery after 55 years: A systematic review of the scientific evidence. Clin Immunol Orlando Fla 2010;135:347–63. doi: 10.1016/j.clim.2010.01.006. 9. 赵铁梅; 解立新; 王艳平; 王桥霞; 齐菲; 陈良安; 以反复呼吸道感染伴呼吸衰竭为突出表现的 Good’s 综合征 1 例报告并文献复习. 北京医学 2008;30:177–8. doi: 10.3969/j.issn.0253-9713.2008.03.016. 10. Tarr PE, Sneller MC, Mechanic LJ, Economides A, Eger CM, Strober W, et al. Infections in patients with immunodeficiency with thymoma (Good syndrome). Report of 5 cases and review of the literature. Medicine (Baltimore) 2001;80:123–33. doi: 10.1097/00005792-200103000-00005. |
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