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本期直播主题：经典必读综述《癌症的特征》，它又更新啦！ 点击预约按钮，领开播好礼！ 是的，十年磨一剑的经典必读重磅综述——Hallmarks of Cancer，于上周刚刚发布它的最新篇：New Dimensions。这篇十年磨一剑的超重磅综述迎来了它的第三版。它同时也是今晚老谈酸菜的直播主题。第一篇Hallmarks of Cancer，在2000 年，由瑞士Agora 转化癌症研究中心的Douglas Hanahan 教授和麻省理工学院的Robert A. Weinberg 教授共同在著名的Cell 上发表，目前已被引超3万次。第二篇Hallmarks of Cancer：Next generation，在2011 年，还是在Cell 杂志，由两位教授对内容进行了更新，已被引超5万次。今年的Hallmarks of Cancer发表在了Cancer Discovery(IF：39.397)，该期刊是美国癌症研究协会主办的期刊，在肿瘤研究领域有着极高的影响力，而 作者也只剩下Hanahan 教授一人，毕竟Weinberg 教授已经80 岁高龄。 
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity of cancer phenotypes and genotypes into a provisional set of underlying principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have emerged as potential refinements. Herein, the prospect is raised that phenoty picplasticity and disrupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogramming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added to the roster of functionally important cell types in the tumor microenvironment.癌症概念化的特征是一种启发式工具，将超级复杂的癌症表型与基因型提炼为一组现行但未来可能出现变动的基本定律。随着人们对癌症发生发展机制的认知逐步完善，该疾病的其他方面已成为潜在的（认知）优化（方向）。本文对未来癌症研究的展望是：表型可塑性和分化中断是一种彼此不相关的标志性能力，并且非突变表观遗传重编程和多态微生物组是促进（癌症）获得标志性能力的独特有利特征。此外，不同来源的衰老细胞可能会被添加到肿瘤微环境重要功能细胞名单中。Significance: Cancer is daunting in the breadth and scope of its diversity, spanning genetics, cell and tissue biology, pathology, and response to therapy. Ever more powerful experimental and computational tools and technologies are providing an avalanche of “big data” about the myriad manifestations of the diseases that cancer encompasses. The integrative concept embodied in the hallmarks of cancer is helping to distill this complexity into an increasingly logical science, and the provisional new dimensions presented in this perspective may add value to that endeavor, to more fully understand mechanisms of cancer development and malignant progression, and apply that knowledge to cancer medicine.意义：癌症在其多样性的广度和范围上令人望而生畏，涉及遗传学、细胞学、组织生物学、病理学以及（癌症）对治疗的反应。越来越强大的实验和运算科技正在提供关于癌症各种表现形式的超体量“大数据”。癌症标志中体现的综合概念有助于将这种复杂性提炼成一门越来越合乎逻辑的科学，在这个视角中呈现的现行新维度可能会为更全面地了解癌症发展和恶性进展的机制所付出的努力增加价值，并且将这些知识应用于癌症医学。担心这篇综述太过难读？ 请记得收看今晚的酸谈直播
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