总结: ◆ 本例病例结合形态学表现,免疫表型E-cadherin阳性,易被误诊为非特殊型浸润性癌,这时需联合P120胞浆阳性进行鉴别。 ◆ 我们在日常工作中,应结合形态学表现及免疫表型综合诊断。 参考文献: 【1】Ciriello G, Gatza M L, Beck A H,et al.Comprehensivemolecular portraits of invasive lobular breast cancer.Cell,2015,163(2),506-519. 【2】Iorfida M, Maiorano E, Orvieto E,et al.Invasivelobular breast cancer: subtypes and outcome.Breast Cancer Res Treat,2012,133(2),713-723. 【3】梅开勇,郭双平主译,《乳腺病理学》,2021,206-212. 【4】Grabenstetter A, Mohanty A S, Rana S,etal.E-cadherin immunohistochemical expression in invasive lobular carcinoma ofthe breast: correlation with morphology and CDH1 somatic alterations.HumPathol. 2020 ; 102(8): 44–53. 【5】Lokuhetty D, White VA, Watanabe R, et al.WHOClassification of Tumours Editorial Board Breast tumors. IARC: Lyon; 2019. 【6】李国霞主译,《乳腺病理活检解读》第3版,2019年. 【7】阚秀,丁华野,沈丹华主编,《乳腺肿瘤临床病理学》,2014. 【8】Bonacho T, Rodrigues F., Liberal J,et al.Immunohistochemistry fordiagnosis and prognosis of breast cancer: a review.Biotechnic &Histochemistry,2019,1052-0295. 本内容纯属学术交流,请批评指正。 供稿 | 袁俊清 排版 | liao 审核 | Jaylon
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