1 昼夜节律
昼夜节律产生的分子基础是时钟基因转录-翻译-反馈环路在24 h内节律性运行[1]。中央时钟基因位于下丘脑视交叉上核(hypothalamic suprachiasmatic nucleus,SCN),产生中央昼夜节律,受光信号调控。SCN既能通过与下丘脑室旁核的联系控制自主神经系统(ANS),通过ANS将时间信号传递至大部分外周组织器官,也能通过交感神经支配松果体分泌褪黑素(melatonine,MT),参与体液循环,将时间信息传递至外周组织,使外周节律同中央节律保持一致。
肠运动昼夜节律及其外科临床意义 潘华峰,王 刚,江志伟 中国实用外科杂志,2022,42(3):355-357 肠运动存在昼夜节律,表现为白天活跃,夜间减弱或消失,这是一种内生性的、由时钟基因控制的生物节律。肠运动节律既可与中央节律保持高度一致,也可独立于中央节律而对外周环境刺激做出反馈。外科手术会破坏肠运动的昼夜节律,而围手术期合理使用褪黑素、五羟色胺(5-HT)受体激动剂和非甾体类解热镇痛药等药物则有助于促进此节律的恢复。外科医生了解肠运动节律的机制,有助于加深术后肠麻痹(POI)的认识,再基于时辰药理学,在合适的时机以适宜的剂量给药,或许能进一步缩短POI时间,促进肠运动功能尽早恢复。 基金项目:江苏省中医药管理局重点项目(No.ZD201903);江苏省中医院科研课题基金(No.Y2019CX25) 作者单位:南京中医药大学附属医院普外科,江苏南京210002 通信作者:江志伟,E-mail:surgery1@aliyun.com 1 昼夜节律
2 肠运动自主节律和昼夜节律
3 外科学意义
4 结语
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