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Clinicopathological characteristics of colorectal serrated polyposis syndrome (SPS): results of a multicenter study by the SPS Study Group in Japan 结直肠锯齿状息肉病综合征（SPS）的临床病理学特征：日本SPS研究组的多中心研究结果 Background 背景 Serrated polyposis syndrome (SPS), a type of colorectal polyposis characterized by multiple serrated polyps, is associated with a high risk of colorectal carcinoma (CRC). This study aimed to clarify the clinicopathological characteristics of SPS in Japan. 锯齿状息肉病综合征（SPS）是一种以多发锯齿状息肉为特征的结直肠息肉疾病，与较高风险的结直肠癌（CRC）有关。本研究旨在阐明日本SPS的临床病理特征。 Methods 方法 We investigated the clinicopathological characteristics of patients with SPS from the “Multicenter Study on Clinicopathological Characteristics of SPS (UMIN 000032138)” by the Colorectal Serrated Polyposis Syndrome (SPS) Study Group. In this study, patients were diagnosed with SPS based on the 2019 World Health Organization (WHO) SPS diagnostic criteria. 我们从结直肠锯齿状息肉病综合征（SPS）研究组的“SPS临床病理学特征多中心研究（UMIN000032138）”中调查了SPS患者的临床病理学特征。在本研究中，患者根据2019年世界卫生组织（WHO）SPS诊断标准被诊断为SPS。 2019 World Health Organization (WHO) SPS diagnostic criteria. 2019年世界卫生组织（WHO）SPS诊断标准 I) ≥ 5 Serrated lesions/polyps proximal to the rectum, all being ≥ 5 mm in size, with ≥ 2 being ≥ 10 mm in size I) ≥5个直肠近端锯齿状病变/息肉，均≥5mm，其中≥2个的病变≥10mm II) > 20 Serrated lesions/polyps of any size distributed throughout the large bowel, with ≥ 5 being proximal to the rectum. II) >20个任何大小的锯齿状病变/息肉，分布于整个大肠肠腔，其中≥5个位于直肠近端。 Results 结果 Ninety-four patients were diagnosed with SPS in 10 institutions between January 2001 and December 2017. The mean number (± standard deviation [SD]) of resected lesions per patient was 11.3 ± 13.8. The mean age at diagnosis of SPS was 63.3 ± 11.6 years, and 58 patients (61.7%) were male. Eighty-seven (92.6%) and 16 (17.0%) patients satisfied WHO diagnostic criteria I and II, respectively. Nine patients (9.6%) satisfied both criteria I and II. Carcinoma (T1–T4) were observed in 21 patients (22.3%) and 24 lesions. Of the 21 patients with CRC, 19 (90.4%) satisfied diagnostic criterion I, 1 (4.8%) satisfied diagnostic criterion II, and 1 (4.8%) satisfied diagnostic criteria I and II. There was no notable difference in the prevalence of CRC among patients who met diagnostic criterion I, II, and both I and II. 2001年1月至2017年12月期间，10家医疗机构中共94例患者被诊断为SPS。每例患者切除的平均病灶数量（±标准差[SD]）为11.3±13.8个。患者被诊断为SPS的平均年龄为63.3±11.6岁，其中58例患者（61.7%）为男性。根据WHO诊断标准，被诊断为I型和II型息肉的患者分别为87例（92.6%）和16例（17.0%）。此外，有9例患者（9.6%）同时满足I型和II型病变的标准。我们在21例患者（22.3%）中观察到癌变（T1-T4），共涉及24个病灶。在这21例结直肠癌患者中，19例（90.4%）为WHO I型病变，1例（4.8%）为II型病变，还有1例（4.8%）同时满足I型和II型。在符合WHO I型、II型以及I型&和II型的患者中，CRC的患病率没有显著差异。 Conclusions 结论 Patients with SPS have a high risk of CRC and should undergo regular surveillance colonoscopy. Raising awareness of this syndrome is crucial. SPS患者发生CRC的风险很高，应定期进行结肠镜检查。此外，提高对这种综合征的认识至关重要。 Reference: Shimohara, Y., Urabe, Y., Oka, S. et al. Clinicopathological characteristics of colorectal serrated polyposis syndrome (SPS): results of a multicenter study by the SPS Study Group in Japan. J Gastroenterol 57, 300–308 (2022). https:///10.1007/s00535-022-01859-7 声明： 本文翻译为来自柳叶新潮团队编辑整理，仅供学习交流，欢迎个人转发至朋友圈。
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