● VirusDIP 截至5月8日12时,CNGBdb病毒数据库(VirusDIP): > 总数据量:GISAID EpiCoV™ 17453条,CNGBdb新冠病毒数据库2196 条; > 上周新增(5.2~5.8):GISAID EpiCoV™ 1865条,CNGBdb新冠病毒数据库190条; > CNGBdb归档:75条新冠病毒组装数据,83条新冠病毒测序数据(其中32条为公开数据)。 👉 点击阅读原文访问VirusDIP 每周 CNGBdb为您精选 COVID-19一周研究速览 预印本 预印本网站:medRxiv > 标题:一对非竞争性人中和抗体阻断COVID-19病毒与其受体ACE2的结合 > 主要结论:中和抗体可能是抗COVID-19大流行的抗病毒药物。本文报道了从我国一例康复患者中分离到的4株人源性单克隆抗体。所有这些抗体在体外均显示出中和能力。我们的研究结果突出了抗体治疗的前景,为合理的疫苗设计提供了结构基础。 > DOI: https:///10.1101/2020.05.01.20077743. 预印本网站:bioRxiv > 标题:ACE2中的错义变异体可促进和抑制与SARS-CoV-2 S蛋白的相互作用,并增加COVID-19的遗传风险 > 主要结论:本文揭示了ACE2亲和力变化的突变体对COVID-19影响的遗传关联,也为设计具有可调控亲和力的ACE2突变体提供依据,这可能是对目前正在进行重组ACE2的临床试验提出改进建议。 > DOI: https:///10.1101/2020.05.03.07478. 参考文献: [1] Watanabe Y, Allen JD, Wrapp D., et al. Site-specific glycan analysis of the SARS-CoV-2 spike. Science. 2020 May 4. pii: eabb9983. [2] Qiang Gao1,Linlin Bao2,Haiyan Mao,et al. Development of an inactivated vaccine candidate for SARS-CoV-2. Science 06 May 2020:eabc1932. [3] Jin, Z., Zhao, Y., Sun, Y. et al. Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur. Nat Struct Mol Biol (2020). [4] Wrapp D, De Vlieger D, Corbett K S, et al. Structural Basis for Potent Neutralization of Betacoronaviruses by Single-domain Camelid Antibodies[J]. Cell, 2020. [5] Wang, C., Li, W., Drabek, D. et al. A human monoclonal antibody blocking SARS-CoV-2 infection. Nat Commun 11, 2251 (2020). [6] Thao, T.T.N., Labroussaa, F., Ebert, N. et al. Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform. Nature (2020). [7] Weitz, J.S., Beckett, S.J., Coenen, A.R. et al. Modeling shield immunity to reduce COVID-19 epidemic spread. Nat Med (2020). [8] Wen, W., Su, W., Tang, H. et al. Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing. Cell Discov 6, 31 (2020). [9] Yan Wu,et al.A non-competing pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2.medRxiv. 07 May , 2020. [10] Stuart A. MacGowan,et al.Missense variants in ACE2 are predicted to encourage and inhibit interaction with SARS-CoV-2 Spike and contribute to genetic risk in COVID-19.bioRxiv. 04 May , 2020. 部分信息来源于“BioArtReports”公众号,如有侵权请联系删除。 *注:中文翻译仅供参考,一切内容以英文原文为准。以上内容仅代表文章作者本人观点,不代表深圳国家基因库生命大数据平台观点或立场。 |
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