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乳腺癌仍然是女性癌症相关死亡的主要原因，深刻反映其疾病异质性、转移性和治疗耐药性。近十年来，基因组和转录组数据以前所未有的规模整合，揭示了不同的癌症亚型、关键分子驱动因素、克隆进化轨迹和预后特征。此外，高分辨率单细胞技术和空间技术的多维整合，突出了整个乳腺癌生态系统的重要性以及不同细胞的“邻里”关系。在临床上，出现了大量新的靶向药物，现在正被迅速纳入常规治疗。不过，对治疗的耐药仍然是该领域的关键挑战之一。 2023年3月16日，全球自然科学三大旗舰期刊之一、美国《细胞》正刊发表新西兰奥克兰大学、澳大利亚墨尔本大学、沃尔特和伊丽莎·霍尔医学研究所、彼得·麦卡伦癌症中心的综述，从生物学机制到临床，对乳腺癌进行了破译，全文共计21页，主要内容包括：传统的乳腺癌分类、乳腺癌的分子学亚型、乳腺癌的基因组谱、肿瘤进展期间克隆进化的动力学、家族性乳腺癌、乳腺肿瘤形成的主要信号传导通路、肿瘤微环境、细胞空间组织结构及其“邻里”关系、乳腺癌现有治疗方法。靶向乳腺癌的关键信号传导节点，以及传统和新型疗法的示例Cell. 2023 Mar 16. IF: 66.850Deciphering breast cancer: from biology to the clinic.Emma Nolan, Geoffrey J. Lindeman, Jane E. Visvader.University of Auckland, Auckland, New Zealand; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; University of Melbourne, Parkville, VIC, Australia; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.Breast cancer remains a leading cause of cancer-related mortality in women, reflecting profound disease heterogeneity, metastasis, and therapeutic resistance. Over the last decade, genomic and transcriptomic data have been integrated on an unprecedented scale and revealed distinct cancer subtypes, critical molecular drivers, clonal evolutionary trajectories, and prognostic signatures. Furthermore, multi-dimensional integration of high-resolution single-cell and spatial technologies has highlighted the importance of the entire breast cancer ecosystem and the presence of distinct cellular “neighborhoods.” Clinically, a plethora of new targeted therapies has emerged, now being rapidly incorporated into routine care. Resistance to therapy, however, remains a crucial challenge for the field.DOI: 10.1016/j.cell.2023.01.040
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