导语: 图1. PIT-1 参与垂体前叶细胞分化 根据2017版WHO新分类,PIT-1阳性谱系腺瘤包括生长激素细胞腺瘤、泌乳激素细胞腺瘤、促甲状腺激素细胞腺瘤、PIT-1阳性激素阴性腺瘤和多激素PIT-1阳性腺瘤(以前称为静止性第三亚型腺瘤)。 生长激素腺瘤 泌乳素腺瘤 促甲状腺激素腺瘤 PIT-1阳性激素阴性腺瘤 PIT-1阳性激素阴性腺瘤表达PIT-1但不表达GH、PRL或TSH,它们可能导致GH、PRL或TSH或其中两种激素的功能亢进,应被指定为(低分化)PIT阳性、激素阴性的腺瘤。 多激素PIT-1阳性腺瘤腺瘤 多激素PIT-1阳性腺瘤(静止性第三亚型腺瘤)侵袭性高、易复发、无病生存率低。John P. Andrews等人对Medline和Google Scholarzhong 1990-2020的病例进行了荟萃分析,并回顾了2012-2019年在自己所在中心手术治疗的腺瘤,结果表明该肿瘤的病理特征为:所有肿瘤都表现出单形性特征,转录因子PIT-1呈核弥漫强阳性表达,腺瘤细胞不同程度表达GH、PRL、TSH和α亚基,但不表达SF-1和T-PIT,如图4所示。 图4. 多激素PIT-1阳性腺瘤免疫组化特征 A: 苏木精伊红染色;B: 转录因子PIT-1弥漫强阳性;C-E:GH、PRL、TSH染色 迈新相关抗体
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