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【每周三句半，一起读文献】 Predictors for Cerebral Edema in Acute Ischemic Stroke Treated With Intravenous Thrombolysis 静脉溶栓治疗后脑水肿发生的预测因素  1.Cerebral edema (CED) is a severe complication of acute ischemic stroke. There is uncertainty regarding the predictors for the development of CED after cerebral infarction. We aimed to determine which baseline clinical and radiological parameters predict development of CED in patients treated with intravenous thrombolysis. 词汇：
例句：Cerebral edema or cerebral oedema is excess accumulation of fluid in the intracellular or extracellular spaces of the brain。
例句：The methods of thrombolytic therapy include intravenous thrombolysis, intra-arterial thrombolysis, and a combination of both. 译文： 脑水肿（CED）是急性缺血性卒中的严重并发症。脑梗死后CED发展的预测因素目前还不确定。我们旨在确定哪些基线临床和放射学参数有哪些能够预测静脉溶栓患者脑水肿发展进程的临床和影像学基线参数。 注： CED是急性缺血性卒中的严重并发症，占所有脑梗死死亡数的5%。毛细血管内皮功能障碍会损伤血脑屏障，从而引起CED。CED会导致组织变化及增加颅内压，通常在卒中后2-15天内导致死亡发生。临床研究表明，接受静脉溶栓（IVT）的缺血性卒中患者出现CED的风险没有明显增加，但有研究证据表明IVT会损伤血脑屏障，引起CED。 2. We used an image-based classification of CED with 3 degrees of severity (less severe CED 1 and most severe CED 3) on postintravenous thrombolysis imaging scans. We extracted data from 42 187 patients recorded in the SITS International Register (Safe Implementation of Treatments in Stroke) during 2002 to 2011. We did univariate comparisons of baseline data between patients with or without CED. We used backward logistic regression to select a set of predictors for each CED severity. 词汇：
例句：Univariate linear correlation analysis was used for comparison among the variables.
例句：It is meaningless to say that something can cause cancer without extensive baseline data about dosage, proximity, exposure and other factors that fracturing opponents never discuss. 译文： 研究纳入了2002-2011年期间来自41个国家752个中心在SITS―ISTR（卒中治疗安全实施-国际卒中溶栓登记处）中的42187例IVT治疗的缺血性卒中患者。基于静脉溶栓后影像学结果将CED的严重程度分为3级（较轻的CED1和最严重的CED3）。对出现CED和未出现CED的患者的基线数据进行单变量比较，最后通过逆向logistic回归分析每种CED严重等级的预测因素。 3.CED was detected in 9579/42187 patients (22.7%: 12.5% CED 1, 4.9% CED 2, 5.3% CED 3). In patients with CED versus no CED, the baseline National Institutes of Health Stroke Scale score was higher (17 versus 10; P<0.001), signs="" of="" acute="" infarct="" was="" more="" common="" (27.9%="" versus="" 19.2%;=""><0.001), hyperdense="" artery="" sign="" was="" more="" common="" (37.6%="" versus="" 14.6%;=""><0.001), and="" blood="" glucose="" was="" higher="" (6.8="" versus="" 6.4="" mmol/l;=""><0.001). baseline="" national="" institutes="" of="" health="" stroke="" scale,="" hyperdense="" artery="" sign,="" blood="" glucose,="" impaired="" consciousness,="" and="" signs="" of="" acute="" infarct="" on="" imaging="" were="" independent="" predictors="" for="" all="" edema=""> 词汇：
译文： 在42187例患者中有9579例出现CED（22.7%），其中CED1、CED2、CED3的比例分别为12.5%、4.9%和5.3%。出现CED患者相较于未出现CED患者的基线NIHSS评分增加7分（17 vs 10，p＜0.001），意识水平下降增加了18%（16.6 vs 34.2，p＜0.001），急性梗死症状更为常见（27.9% vs 19.2%，p＜0.001），动脉高密度征更为常见（37.6% vs 14.6%，p＜0.001），血糖更高（6.8 vs 6.4 mmol/L，p＜0.001）。对所有的水肿类型来说，基线NIHSS评分、HAS、血糖水平、意识水平下降和急性梗死症状都是独立的预测因素。 ？你来翻译一句吧： The most important baseline predictors for early CED are National Institutes of Health Stroke Scale, hyperdense artery sign, higher blood glucose, decreased level of consciousness, and signs of infarct at baseline. The findings can be used to improve selection and monitoring of patients for drug or surgical treatment. 上期译文： Available clinical evidence from several single-center studies and limited multicenter studies demonstrates that immediate and direct MT is equally effective and not inferior to bridging thrombolysis if patients are immediately treated in a stroke center with rapid access to endovascular procedures. 来自多个单中心研究和有限多中心研究的临床证据表明，如果患者立即在卒中中心快速接受血管内治疗，立即直接行机械血栓切除术和桥接溶栓治疗同样有效，效果并不弱于后者。 文献来源： |
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