关于叶酸与乳腺癌发生风险的相关性,既往流行病学回顾研究报告的结果不一。 2019年1月15日,英国《自然》旗下《欧洲临床营养杂志》在线发表中国重庆西南大学食品科学学院、山东济宁泗水人民医院的研究报告,对目前已发表的叶酸摄入量与乳腺癌风险前瞻研究结果进行了荟萃分析。 该研究利用PubMed和EMBASE数据库对已发表文献进行系统检索,共纳入23项前瞻研究,对其中4万1516例患者和117万1048例个体进行荟萃分析。 结果发现,叶酸摄入较多与较少相比:
叶酸摄入量每增加100μg/g:
此外,叶酸摄入较多与较少相比:
因此,根据该研究结果表明,叶酸摄入较多,可能减少绝经前乳腺癌、雌激素受体阴性乳腺癌、双激素受体阴性乳腺癌、酒精摄入较多女性乳腺癌的发生风险。 Eur J Clin Nutr. 2019 Jan 15. [Epub ahead of print] Folate intake and the risk of breast cancer: an up-to-date meta-analysis of prospective studies. Jie Zeng, Kun Wang, Fayin Ye, Lin Lei, Yun Zhou, Jia Chen, Guohua Zhao, Hui Chang. College of Food Science, Southwest University, Chongqing, China; People's Hospital of Sishui County, Jining, Shandong, China. Epidemiological studies focusing on the association between folate and breast cancer risk reported inconsistent findings. We conducted a systematic search of the literature using PubMed and EMBASE databases. A total of 23 prospective studies involving 41,516 cases and 1,171,048 individuals were included for meta-analysis. Folate intake may decrease the risk of oestrogen receptor (ER) negative (-) and ER-/progesterone receptor (PR)- breast cancer, with pooled risk ratios (RRs) of 0.88 [95% confidence interval (CI): 0.78-1.00] and 0.82 (95% CI: 0.68-0.97), respectively. An increment of folate intake of 100 μg per day was associated with a deceased risk of ER- (RR = 0.94, 95% CI: 0.88-0.99) and ER-/PR- (RR = 0.90, 95% CI: 0.85-0.97) breast cancer. Moreover, high folate intake may have preventive effects against breast cancer in premenopausal women (RR = 0.94, 95% CI: 0.88-1.00) and individuals with moderate or high levels of alcohol consumption (RR = 0.82, 95% CI: 0.72-0.94). DOI: 10.1038/s41430-019-0394-0 |
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