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Unhealthy foods may attenuate the beneficial relation of a Mediterranean diet to cognitive decline 不健康的食物可能会减弱地中海饮食与认知衰退的有利关系 10.1002/alz.12277 01-07, Article Abstract & Authors:展开 Abstract:收起
INTRODUCTION: It is unclear whether eating Western diet food components offsets the Mediterranean diet's (MedDiet) potential benefits on cognitive decline.
METHODS: The study includes 5001 Chicago Health and Aging Project participants (63% African American, 36% males, 74 ± 6.0 years old), with food frequency questionnaires and ≥ two cognitive assessments over 6.3 ± 2.8 years of follow-up. Mixed-effects models were adjusted for age, sex, education, race, cognitive activities, physical activity, and total calories.
RESULTS: Stratified analysis showed a significant effect of higher MedDiet on cognitive decline only with a low Western diet score (highest vs lowest MedDiet tertile: β = 0.020, P = .002; p trend = 0.002) and not with a high Western diet score (highest vs lowest MedDiet tertile: β = 0.010, P = .11; p trend = 0.09).
CONCLUSION: This prospective study found that high consumption of Western diet components attenuates benefits of the MedDiet on cognition.
First Authors:
Puja Agarwal Correspondence Authors:
Puja Agarwal All Authors:
Puja Agarwal,Klodian Dhana,Lisa L Barnes,Thomas M Holland,Yanyu Zhang,Denis A Evans,Martha Clare Morris
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