觉醒时代,营养战场等你来! ▲ 点击了解2021夏季招募 母乳是宝宝的第一口粮食,其丰富的营养可以让宝宝只依靠母乳度过人生的前6个月。不仅如此,母乳也是宝宝肠道菌群的生命之源,其中的母乳低聚糖帮助有益菌在肠道中生生不息,间接促进宝宝健康成长。 「极养®视界」科普实验室 原创出品 授权方可转载 文章|Jiaqi Xu BS, RD 校稿|Haoran PHD 编审|Xinyin PHD 编辑|Jiaqi Xu BS, RD 设计|Fay 阅读信息 📖 难度:★★☆☆☆ 类型:机理 字数:2026 文章纲要
肠道菌群出没 益生菌定植三部曲 母乳中的全能王 益生菌需要产生SCFA来改变pH防止有害菌入侵[16] 母乳低聚糖就用作益生元供给原料[15] 益生菌缩小肠道细胞间隙将敌人拦在外面[15] 母乳低聚糖调节体液和细胞免疫准备战斗[15] 益生菌抢占致病菌的黏附点位和食物,使其不能安身立命[15] 母乳低聚糖伪装易容,守株待兔,阻断致病菌对肠道细胞的黏附[15]。 “黄金搭档”成就母乳好口碑 ■■ 参考文献 [1] Weaver LT, Austin S, Cole TJ. Small intestinal length: a factor essential for gut adaptation. Gut. 1991;32(11):1321–1323. doi:10.1136/gut.32.11.1321 [2] Milani C, Duranti S, Bottacini F, et al. The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota[J]. Microbiology & Molecular Biology Reviews Mmbr, 2017, 81(4):e00036-17. [3] Walker RW, Clemente JC, Peter I, Loos RJF. The prenatal gut microbiome: are we colonized with bacteria in utero?. Pediatr Obes. 2017;12 Suppl 1(Suppl 1):3–17. doi:10.1111/ijpo.12217 [4] Brosseau C, Selle A, Palmer DJ, Prescott SL, Barbarot S, Bodinier M. Prebiotics: Mechanisms and Preventive Effects in Allergy. Nutrients. 2019;11(8):1841. Published 2019 Aug 8. doi:10.3390/nu11081841 [5] Sohail MU, Althani A, Anwar H, Rizzi R, Marei HE. Role of the Gastrointestinal Tract Microbiome in the Pathophysiology of Diabetes Mellitus. J Diabetes Res. 2017;2017:9631435. doi:10.1155/2017/9631435 [6] Li J, Zhao F, Wang Y, et al. Gut microbiota dysbiosis contributes to the development of hypertension. Microbiome. 2017;5(1):14. Published 2017 Feb 1. doi:10.1186/s40168-016-0222-x [7] Zhuang H, Cheng L, Wang Y, et al. Dysbiosis of the Gut Microbiome in Lung Cancer. Front Cell Infect Microbiol. 2019;9:112. Published 2019 Apr 18. doi:10.3389/fcimb.2019.00112 [8] Fernández MF, Reina-Pérez I, Astorga JM, Rodríguez-Carrillo A, Plaza-Díaz J, Fontana L. Breast Cancer and Its Relationship with the Microbiota. Int J Environ Res Public Health. 2018;15(8):1747. Published 2018 Aug 14. doi:10.3390/ijerph15081747 [9] Plaza-Díaz J, Álvarez-Mercado AI, Ruiz-Marín CM, et al. Association of breast and gut microbiota dysbiosis and the risk of breast cancer: a case-control clinical study. BMC Cancer. 2019;19(1):495. Published 2019 May 24. doi:10.1186/s12885-019-5660-y [10] Marchesi JR, Adams DH, Fava F, et al. The gut microbiota and host health: a new clinical frontier. Gut. 2016;65(2):330–339. doi:10.1136/gutjnl-2015-309990 [11] McGuire MK, McGuire MA. Human milk: mother nature's prototypical probiotic food?. Adv Nutr. 2015;6(1):112–123. Published 2015 Jan 15. doi:10.3945/an.114.007435 [12] Sakata, H., Yoshioka, H., & Fujita, K. (1985). Development of the intestinal flora in very low birth weight infants compared to normal full-term newborns. European Journal of Pediatrics, 144(2), 186–190. doi:10.1007/bf00451911 [13] Keunen K, van Elburg RM, van Bel F, Benders MJ. Impact of nutrition on brain development and its neuroprotective implications following preterm birth. Pediatr Res. 2015;77(1-2):148–155. doi:10.1038/pr.2014.171 [14] Backhed F, Roswall J, Peng Y, et al. Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life. Cell Host Microbe 2015;17:852. [PubMed: 26308884] [15] L. Bode, “Human milk oligosaccharides: every baby needs a sugar mama,” Glycobiology, vol. 22, no. 9, pp. 1147–1162, 2012. [16] Alessandri G, Ossiprandi MC, MacSharry J, van Sinderen D, Ventura M. Bifidobacterial Dialogue With Its Human Host and Consequent Modulation of the Immune System. Front Immunol. 2019;10:2348. Published 2019 Oct 1. doi:10.3389/fimmu.2019.02348 [17] Johnson-Henry KC, Abrahamsson TR, Wu RY, Sherman PM. Probiotics, Prebiotics, and Synbiotics for the Prevention of Necrotizing Enterocolitis. Adv Nutr. 2016;7(5):928–937. Published 2016 Sep 15. doi:10.3945/an.116.012237 [18] Dogaru CM, Nyffenegger D, Pescatore AM, Spycher BD, Kuehni CE: Breastfeeding and childhood asthma: systematic review and meta-analysis. Am J Epidemiol 2014;179:1153-1167. [19] Abrahamsson TR, Jakobsson HE, Andersson AF, Bjorksten B, Engstrand L, Jenmalm MC. Low gut microbiota diversity in early infancy precedes asthma at school age. Clin Exp Allergy (2014) 44:842–50. doi: 10.1111/cea.12253 [20] Brosseau C, Selle A, Palmer DJ, Prescott SL, Barbarot S, Bodinier M. Prebiotics: Mechanisms and Preventive Effects in Allergy. Nutrients. 2019;11(8):1841. Published 2019 Aug 8. doi:10.3390/nu11081841 [21] Thai JD, Gregory KE. Bioactive Factors in Human Breast Milk Attenuate Intestinal Inflammation during Early Life. Nutrients. 2020;12(2):581. Published 2020 Feb 23. doi:10.3390/nu12020581 |
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