  1084-70ish F with persistent HPV+ ASCH cervical cytology and unsatisfactory colposcopy who underwent LEEP.
Adenoid Basal-like Tumor in Cervical LEEP Differential Diagnosis ·HPV-associated cervical carcinoma · Mixed squamous cell carcinoma and adenocarcinoma (”adenosquamous”) · Adenocarcinoma with areas of stratified mucinous carcinoma (iSMILE) · Adenoid basal tumor ·HPV-independent cervical carcinoma · Mesonephric carcinoma (although these usually arise deep in the cervical wall where mesonephric remnants exist) · Direct extension of endometrial carcinoma into cervix
Adenoid Basal-Like Tumors of the Cervix · Rare finding in cervix · Usually incidental when pure; but often admixed with usualtype HPV-associated cervical carcinomas · Resembles basal cell hyperplasia in the prostate · Biphasic, nested growth pattern · Peripheral cells = basaloid with palisading · Central cells = glandular
Key Points – Adenoid Basal Tumor · Rare cervical tumors with a prostatic phenotype · Biphasic tumors resembling basal cell hyperplasia of prostate · NKX3.1+ and HRHPV+ is an unusual IHC combination, unique to this entity · Adenoid basal tumors are often admixed with traditional HPVassociated adenocarcinoma / squamous cell carcinoma with a minor adenoid basal component · Pure adenoid basal tumor is very rare, but have benign behavior thus far · Must recommend further excision if lesion extends to the margin to exclude a component of conventional HPV-associated carcinoma References · Stewart CJR, Moses J. NKX3.1 expression in cervical 'adenoid basal cell carcinoma': another gynaecological lesion with prostatic differentiation? Pathology. 2021 Feb;53(2):193-198. Epub 2020 Oct 5. PMID: 33032811. · Russell MJ, Fadare O. Adenoid basal lesions of the uterine cervix: evolving terminology and clinicopathological concepts. Diagn Pathol. 2006 Aug 15;1:18.. PMID: 16911774; PMCID: PMC1564042. 1085-永不厌倦经典肿瘤类型 女性，30多岁，大腿有肿块。  病变的两个组成部分突然转变为边界清晰的结节。高级别成分较深，看起来是假包膜的 低级和高级梭形细胞成分 CD34 高级别成分的过渡和高倍镜HE 低级是CD34阳性，高级几乎完全失去CD34。 这是DFSP的纤维肉瘤样变。 FISH证实了COL1A1-PDGFB重排。 |
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