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麻醉药物的选择对电休克治疗癫痫发作持续时间的影响：依托咪酯与美索比妥的比较
贵州医科大学 麻醉与心脏电生理课题组 翻译：宋雨婷 编辑：陈锐 审核：曹莹  摘要 背景：许多用于电休克治疗的麻醉药物具有抗惊厥的作用，并可能影响电休克治疗的疗效。这项试验旨在研究依托咪酯和美索比妥对癫痫发作持续时间的影响。该项研究探讨了诱导药物，运动性癫痫发作持续时间和脑电图记录下的癫痫发作持续时间三者之间的关系，癫痫发作持续时间与治疗次数的关系。 方法：此项回顾性研究收集了从2005年至2016年的患者数据。纳入标准为使用依托咪酯和/或美索比妥并记录其剂量、电休克治疗剂量和癫痫发作持续时间的数据。排除标准为缺少诱导药物、剂量或癫痫发作持续时间的数据。 结果：共纳入37名患者，平均年龄为52岁，76%为女性。大多数患者患有情感障碍（81%）。分别对679个电休克治疗的运动性癫痫发作持续时间参数和551个电休克治疗的脑电图记录下的癫痫发作持续时间参数进行分析。与美索比妥相比，使用依托咪酯后的运动性癫痫发作持续时间和脑电图记录下的癫痫发作分别长7s和13 s。此外，癫痫发作持续时间与治疗次数之间，癫痫发作持续时间与电休克治疗剂量之间存在负相关。 结论：该研究表明，与美索比妥相比，使用依托咪酯后的运动性癫痫发作持续时间和脑电图记录下的癫痫发作持续时间明显更长。因此，依托咪酯可能会增加电休克治疗的有效性。此外，我们观察到癫痫发作持续时间，治疗次数和电休克治疗剂量之间存在负相关。这项研究填补了美索比妥和依托咪酯作为电休克治疗诱导剂影响电休克治疗疗效的空白。
原始文献来源：Chomrikh, L., Ahmadi, M., Kuijper, T.M.et al. The influence of anaesthetic choice on seizure duration of electroconvulsive therapy; etomidate versus methohexital. BMC Anesthesiol 22, 206 (2022).   The influence of anaesthetic choice on seizure duration of electroconvulsive therapy; etomidate versus methohexital Abstract Background Many of the anaesthetic drugs used for electroconvulsive therapy have anticonvulsant properties and may influence efficacy of electroconvulsive therapy. With this study we aim to provide more information on the effect of etomidate and methohexital on seizure duration. We explore the relationship between induction drug, motor and electroencephalography seizure duration. Moreover, we study the relationship of seizure duration and number of therapies. Methods：In this retrospective study we collected data from patient records from 2005 until 2016. Inclusion criteria were the use of etomidate and/or methohexital and documentation of dosage, electroconvulsive therapy dosage and seizure duration. Exclusion criteria were missing data on either induction drug, dosage or seizure duration. Results：Thirty seven patients were analysed. The mean age was 52 years and seventy six percent were female. Most patients were suffering from affective disorders (81%). Motor and electroencephalography seizure duration were analysed in 679 and 551 electroconvulsive therapies, respectively. Compared to methohexital, motor and electroencephalography seizures under etomidate were 7 and 13 s longer, respectively. Furthermore, there was a negative association between seizure duration and number of treatment and a negative association between seizure duration and electroconvulsive therapy dosage. Conclusions This study demonstrates significant longer motor and electroencephalography seizure duration using etomidate compared to methohexital. Etomidate might therefore increase the effectiveness of electroconvulsive therapy. Moreover, we observed a negative association between seizure duration, number of treatment and electroconvulsive therapy dosage. With this study we contribute to the available literature comparing methohexital and etomidate as induction agents for electroconvulsive therapy. 苟利国家生死以 岂因祸福避趋之 |
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来自： 罂粟花anesthGH > 《待分类》
