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[摘要] 目的 分析糖尿病视网膜病变（DR）患者中各组肾小球率过滤（GFR）、尿微量白蛋白/肌酐（U-mAlb/Cr）的变化关系，以探讨糖尿病视网膜病变与糖尿病肾病的关系。方法 回顾该院住院病历，根据眼科专业眼底检查情况分3组：正常眼底组（NR）、非增殖期视网膜病变组（NPDR）、增殖期视网膜病变组（PDR），收集及计算各组GFR、U-mAlb/Cr及相关临床指标。结果 与NR组相比，DR组患者的GFR明显减低、U-mAlb/Cr明显升高，且随着DR进展，GFR显著下降、U-mAlb/Cr显著升高。同时随着GFR下降，DR的发病率增加且程度加重，当GFR<60 mL/min时，DR的发病率升至83.33%，其中PDR的发病率高达30.35%。 结论 GFR、U-mAlb/Cr均与DR密切相关。DR患者均应列为DN的高危人群，反之筛查GFR、U-mAlb/Cr有异常时应及时筛查眼底。
[关键词] 糖尿病视网膜病变；糖尿病肾病；肾小球率过滤；尿微量白蛋白/肌酐
[中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062（2017）02（b）-0178-03
Correlation between the Diabetic Retinopathy and Glomerular Filtration Rate and Urine Microalbumin or Creatinine
FU Zheng1， ZHU Li-xiu2， LIN Feng-sen1
1.Endocrine Department， Ningde Hospital affiliated to Fujian Medical University， Ningde， Fujian Province， 352100 China；2.Department of Hematology and Rheumatism， Ningde Hospital affiliated to Fujian Medical University， Ningde， Fujian Province， 352100 China
[Abstract] Objective To analyze the changes correlation between the diabetic retinopathy and glomerular filtration rate and urine microalbumin or creatinine in order to study the correlation between the diabetic retinopathy and diabetic nephropathy. Methods The medical records of inpatients were retrospectively analyzed， and the patients were divided into three groups according to the fundus examination situations of ophthalmology specialty， and the GFR， U-mAlb/Cr and related clinical indexes were collected and calculated. Results The GFR obviously decreased in the DR group compared with that in the NR group， and the U-mAlb/Cr obviously increased， with the progress of DR， the GFR obviously decreased and U-mAlb/Cr obviously increased， at the same time， the GFR decreased， and the morbidity of DR increased， at the time of GFR<60 mL/min， the morbidity of DR increased to 83.33% and the morbidity of PDR was as high as 30.35%. Conclusion GFR and U-mAlb/Cr are closely related to the DR， and the DR patients should be ranked as the DN high-risk population， however， we should screen the fundus in time when the GFR and U-mAlb/Cr are abnormal.
[Key words] Diabetic retinopathy； Diabetic nephropathy； Glomerular filtration rate； Urine microalbumin/creatinine
糖尿病?网膜病变（DR）与糖尿病肾病（DN）同属于糖尿病常见的微血管并发症，前者为成年糖尿病患者最常的致盲疾病之一，后者则是终末肾病的主要病因。因糖尿病视网膜病变与糖尿病肾病两者同为微血管损伤，其发病有明显相关性[1]。糖尿病肾病的特征表现为持续的蛋白尿、肾小球率过滤的逐渐下降等。肾小球率过滤（GFR）与尿微量白蛋白/肌酐（U-mAlb/Cr）为简便而有效的评估糖尿病肾病方法。该实验旨在通过评估糖尿病视网膜病变与GFR、U-mAlb/Cr的关系，以探讨糖尿病视网膜病变与糖尿病肾病的关系，现报道如下。
1 资料与方法
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