Differences in subchondral trabecular bone microstructure and finite element analysis-based biomechanical properties between osteoporosis and osteoarthritishttps:///10.1016/j.jot.2020.05.006全文下载地址：扫描文末二维码，关注“我爱背诵”公众号并回复“有限元”获取 SummaryBackground/ObjectiveThe microstructure of the subchondral trabecular bone, including the composition and distribution of plates and rods, has an important influence on the disease progression and mechanical properties of osteoarthritis (OA) and osteoporosis (OP). We aimed to determine whether differences in plates and rods influence the variations in the quantities and qualities of the subchondral trabecular bone between OA and OP. Materials and methodsThirty-eight femoral head samples [OA, n = 13; OP, n = 17; normal control (NC), n = 8] were collected from male patients undergoing total hip arthroplasty. They were scanned using microcomputed tomography, and subchondral trabecular structures were analysed using individual trabecular segmentation. Micro-finite element analysis (μFEA) was applied to assess the mechanical property of the trabecular bone. Cartilage changes were evaluated by using histological assessment. Analysis of variance was used to compare intergroup differences in structural and mechanical properties and cartilage degradation. Pearson analysis was used to evaluate the relationship between the trabecula microstructure and biomechanical properties. ResultsCompared with the OP and NC group, there was serious cartilage damage in the OA group. With respect to the microstructure results, the OA group had the highest plate and rod trabecular microstructures including number and junction density among the three groups. For the mechanical properties detected via μFEA, the OA group had higher stiffness and failure load than did the OP group. Pearson analysis revealed that compared with OP, OA had a higher number of microstructure parameters (e.g., rod bone volume fraction and rod trabecular number) that were positively correlated with its mechanical property. ConclusionsCompared with OP, the OA subchondral bone has both increased plate and rod microarchitecture and has more microstructures positively related with its mechanical property. These differences may help explain the variation in mechanical properties between these bone diseases. 重点词汇汇总： finite element analysis 有限元分析 trabecular /trə'bekjulə/adj. 小梁的；有小带的；有横隔片的 subchondral软骨下的 Cartilage /ˈkɑːrtɪlɪdʒ/n. 软骨 histological /,histə'lɔdʒikəl/adj. 组织学的 degradation /ˌdeɡrəˈdeɪʃn/n. 退化；降格，降级；堕落 biomechanical properties.生物力学特性。 parameter /pəˈræmɪtər/n. 参数；系数；参量 fraction/ˈfrækʃn/n. 分数；部分；小部分；稍微 百度翻译： 骨质疏松症与骨关节炎软骨下骨小梁显微结构及生物力学特性的差异 摘要 背景/目标 软骨下小梁骨的显微结构，包括板和杆的组成和分布，对骨关节炎（OA）和骨质疏松症（OP）的病情发展和力学性能有重要影响。我们的目的是确定板和棒的差异是否影响OA和OP之间软骨下小梁骨数量和质量的变化。 材料和方法 从接受全髋关节置换术的男性患者中采集了38个股骨头样本[OA，n=13；OP，n=17；正常对照组（NC），n=8]。他们被扫描使用微计算机断层扫描，和软骨下小梁结构分析使用个别小梁分割。应用显微有限元分析（μFEA）评价骨小梁的力学性能。用组织学方法评价软骨的变化。采用方差分析比较各组间在结构和力学性能以及软骨降解方面的差异。采用Pearson分析评价骨小梁显微结构与生物力学性能的关系。 结果 与OP组和NC组相比，OA组软骨损伤严重。从显微结构结果来看，OA组的板状和棒状小梁显微结构（数量和连接密度）在三组中最高。对于μFEA检测到的力学性能，OA组的刚度和破坏载荷均高于OP组。Pearson分析表明，与OP相比，OA具有更多的微观结构参数（如杆骨体积分数和杆小梁数），这些参数与骨力学性能呈正相关。 结论 与OP相比，OA软骨下骨具有更多的板状和棒状微结构，具有更多与其力学性能呈正相关的微观结构。这些差异可能有助于解释这些骨疾病之间力学性能的差异。
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