2型糖尿病是一种常见病,65岁以上的老年人,大约20%患有2型糖尿病。即便10-19岁的青少年,每千人就有0.67人患有2型糖尿病。2型糖尿病常并发多种其他疾病,包括心血管病、肥胖以及神经和肾脏的疾病。此外,79%的1型或2型糖尿病患者至少伴有一种皮肤病,如皮肤感染(48%)、干燥(26%)和炎症 (21%)。同时,诸多的研究发现,糖尿病同时伴有表皮功能的改变。 最近,Journal of Diabetes期刊发表了一篇综述,对2型糖尿病表皮功能的改变及其临床意义进行了梳理。 综上所述,2型糖尿病患者伴有表皮功能降低,持续表皮功能降低可导致系统炎症。而炎症与2型糖尿病的发病有关。因此,纠正表皮功能异常和止痒有利于改善2型糖尿病以及炎症衰老相关的疾病。然而,还需要恰当的临床研究来验证这一假设。 相关阅读 最新权威共识:40%糖尿病患者易得慢性肾病,每年筛查是关键!7项核心诊治建议速览 最新中国糖尿病医学营养指南:7大类、86条推荐,表格赶紧收藏! 指南荟萃:医学营养是基础,8种糖尿病饮食方案,适合大多数人吃 参考资料(可上下滑动查看) 1.Elias PM, Arbiser J, Brown BE, et al. Epidermal vascular endothelial growth factor production is required for permeability barrier homeostasis, dermal angiogenesis, and the development of epidermal hyperplasia: implications for the pathogenesis of psoriasis. Am J Pathol. 2008;173(3):689-99. 2.Aberg KM, Man MQ, Gallo RL, et al. Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers. J Invest Dermatol. 2008;128(4):917-25. 3.Choi EH, Brown BE, Crumrine D, et al. Mechanisms by which psychologic stress alters cutaneous permeability barrier homeostasis and stratum corneum integrity. J Invest Dermatol. 2005;124(3):587-95. 4.Wang Z, Man MQ, Li T, et al. Aging-associated alterations in epidermal function and their clinical significance. Aging (Albany NY). 2020;12(6):5551-5565. 5.Elias PM, Wood LC, Feingold KR. Epidermal pathogenesis of inflammatory dermatoses. Am J Contact Dermat. 1999;10(3):119-26. 6.Proksch E, Brasch J. Abnormal epidermal barrier in the pathogenesis of contact dermatitis. Clin Dermatol. 2012;30(3):335-44. 7.Man MQ, Elias PM. Stratum corneum hydration regulates key epidermal function and serves as an indicator and contributor to other conditions. J Eur Acad Dermatol Venereol. 2019;33(1):15-16. 8.Hu L, Mauro TM, Dang E, et al. Epidermal Dysfunction Leads to an Age-Associated Increase in Levels of Serum Inflammatory Cytokines. J Invest Dermatol. 2017;137(6):1277-1285. 9.Ye L, Mauro TM, Dang E, et al. Topical applications of an emollient reduce circulating pro-inflammatory cytokine levels in chronically aged humans: a pilot clinical study. J Eur Acad Dermatol Venereol. 2019;33(11):2197-2201. |
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